https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:41782 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.]]> Wed 22 Mar 2023 14:30:25 AEDT ]]> Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:13924 −11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 x 10⁻⁹, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 x 10⁻¹², OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings¹. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.]]> Sat 24 Mar 2018 08:24:48 AEDT ]]> The long-term relation among retinal arteriolar narrowing, blood pressure, and incident severe hypertension https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5222 Sat 24 Mar 2018 07:44:21 AEDT ]]> Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:32383 20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10 -5 ) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation.]]> Mon 23 Sep 2019 12:09:41 AEST ]]> Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:43046 6.0 mM (strata-specific OR 1.72, 95% CI 1.09–2.72). No similar association was found in participants with normal FBG (OR 0.85, 95% CI 0.69–1.04). This interaction was not evident in the SEED study. Conclusions: The identified interaction between rs9640883 and FBG in relation to cortical cataract was not replicated but may warrant further investigation.]]> Mon 12 Sep 2022 12:59:35 AEST ]]>