https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:52465 Wed 11 Oct 2023 20:36:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:55878 Wed 03 Jul 2024 14:24:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36900 Wed 02 Mar 2022 14:24:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48670 Tue 28 Mar 2023 10:15:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:33789 Tue 15 Jan 2019 12:58:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:35228 in utero. This allows adverse intrauterine conditions to make a sustained impact on the developing brain like in compromised human pregnancies. In addition, the brain is exposed to a protective neurosteroid environment in utero, which has been suggested to promote development in the guinea pig and the human. Moreover, in utero stresses that have been shown to adversely affect long term neurobehavioral outcomes in clinical studies, can be modeled successfully in guinea pigs. Overall, these parallels to the human have led to increasing interest in the guinea pig for translational studies of treatments and therapies that potentially improve outcomes following adverse events in pregnancy and after preterm birth.]]> Tue 02 Jul 2019 11:37:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:35009 A receptor subunits were measured by RT-PCR. Results: MBP immunostaining was increased in lobule IX of preterm males, and reduced in lobule X of preterm females when compared to their term counterparts. GAD67 staining was decreased in lobule IX and X of the preterm males, but only in lobule X of the preterm females compared to term cohorts for each sex. Internal granule cell layer width of lobule X was decreased in preterm cohorts of both sexes compared to terms. There were no differences between gestational age groups for NeuN staining, GAD67 and GAT1 protein expression as measured by western blotting, or GABA_A receptor subunits as measured by RT-PCR between preterm and term for either sex. Conclusions: The present findings suggest that components of the cerebellar GABAergic system of the ex-preterm cerebellum are disrupted. The higher expression of myelin in the preterm males may be due to a deficit in axonal pruning, whereas females have a deficit in myelination at 28 corrected days of age. Together these ongoing alterations may contribute to the neurodevelopmental and behavioural disorders observed in those born preterm.]]> Thu 30 May 2019 14:58:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:36998 Thu 30 Jul 2020 16:59:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:24307 A receptor subunits that normally heighten neurosteroid sensitivity. These stressors also result in altered placental allopregnanolone metabolism pathways. These findings suggest that reduced neurosteroid production and action in the perinatal period may contribute to some of the adverse neurodevelopmental and behavioural outcomes that result from these pregnancy compromises. Studies examining perinatal steroid supplementation therapy with non-metabolisable neurosteroid analogues to improve these outcomes are warranted.]]> Thu 21 Oct 2021 12:51:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:30294 Sat 24 Mar 2018 07:33:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:26441 A receptor subunit expression was also assessed using RT-PCR. Neonates born from mothers stressed during late pregnancy showed a reduction in both MBP (p < 0.01) and GFAP (p < 0.05) expression in the CA1 region of the hippocampus at 21 days of age. Pups of prenatally stressed pregnancies also showed higher levels of anxiety and neophobic behaviours at the equivalent of childhood (p < 0.05). There were no significant changes observed in allopregnanolone levels, 5αR1/2 expression, or GABA_A receptor subunit expression in prenatally stressed neonates compared to controls. This study shows alterations in markers of myelination and reactive astrocytes in the hippocampus of offspring exposed to prenatal stress. These changes are also observed in offspring that show increased anxiety behaviours at the equivalent of childhood, which indicates ongoing structural and functional postnatal changes after prenatal stress exposure.]]> Sat 24 Mar 2018 07:27:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:47891 Mon 06 Feb 2023 12:21:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:50958 Mon 01 Jul 2024 11:10:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:53108 Fri 17 Nov 2023 11:28:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:55359 Fri 17 May 2024 16:05:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:49419 Fri 12 May 2023 15:02:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:37890 Fri 11 Jun 2021 09:29:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:48163 Fri 10 Mar 2023 16:25:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:54686 Fri 08 Mar 2024 11:53:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:54665 Fri 08 Mar 2024 10:57:23 AEDT ]]>