https://nova.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:14536 500 ms was defined as abnormal. Results: Forty-six patients had Holter recordings after 10–40 mg droperidol and 316 QT–HR pairs were included. There were 32 abnormal QT measurements in four patients, three given 10 mg and one 20 mg. In three of the four patients QTcF >500 ms but only in one taking methadone was the timing of QTcF >500 ms consistent with droperidol dosing. Of the three other patients, one took amphetamines, one still had QT prolongation 24 h after droperidol and one took a lamotrigine overdose. No patient given >30 mg had a prolonged QT. There were no arrhythmias. Conclusion: QT prolongation was observed with high dose droperidol. However, there was little evidence supporting droperidol being the cause and QT prolongation was more likely due to pre-existing conditions or other drugs.]]> Wed 11 Apr 2018 11:05:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:55885 Wed 03 Jul 2024 14:59:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:44618 Tue 18 Oct 2022 08:58:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:38989 Python molurus), and one viperid (Trimeresurus trigonocephalus). The snake species that caused the most-number of bites was the Trinket snake (Coelognathus helena) (n = 15). Three species of wolf-snakes, Lycodon aulicus, L. anamallensis, and L. striatus were responsible for 12, 11, and 5 bites respectively. Most of the patients (55%) presented to the local hospital and subsequently transferred to the study hospital for further management. None of the patients developed systemic envenoming and five developed mild local pain and swelling. Fifty-six (74%) patients were discharged on the following day, while 18 (24%) were discharged on the third day. There is a need to educate medical personnel working the peripheral hospital on how to identify medically lesser important snakes to avoid unnecessary transfers.]]> Thu 24 Aug 2023 09:10:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:38297 10,000 U/L)]. The odds of (mild or severe) myotoxicity was lower in patients that received early antivenom (within 6 hours post-bite) compared to those that received late or no antivenom (odd ratio was 0.186; 95% confidence interval, 0.052 – 0.664). A population pharmacokinetic-pharmacodynamic (PKPD) model was developed to describe the relationship between the time course of venom (a mixture of toxins) and effect (elevated CK). In addition, a kinetic-pharmacodynamic (KPD) model was developed to describe the relationship between time course of a theoretical toxin and effect. Model development and parameter estimation was performed using NONMEM v7.3. No single set of parameter values from either the PKPD or KPD models were found that could accurately describe the time course of different levels of severity of myotoxicity. The predicted theoretical toxin half-life from the KPD model was 11 ± 3.9 hours compared to the half-life of venom of 5.3 ± 0.36 hours. This indicates that the putative causative toxin’s concentration-time profile does not parallel that of venom.]]> Thu 16 Nov 2023 12:21:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:39298 Thu 16 Nov 2023 12:19:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:7559 Sat 24 Mar 2018 08:42:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5699 Sat 24 Mar 2018 07:48:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:39103 Mon 09 May 2022 15:34:40 AEST ]]>