https://nova.newcastle.edu.au/vital/access/manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:18998 Wed 20 May 2020 07:08:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:22889 Annals of Oncology online.]]> Wed 11 Apr 2018 11:24:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:29893 Tue 25 Jul 2023 12:08:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:8225 Sat 24 Mar 2018 08:40:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:21434 15% was seen in patients aged <40 years (16.1%), with ≥4 positive nodes (16.5%) or 0–7 uninvolved nodes (15.1%); for supraclavicular failures >10%: ≥4 positive nodes (10.2%); for axillary failures of >5%: aged <40 years (5.1%), unknown primary tumor size (5.2%), 0–7 uninvolved nodes (5.2%). In patients with 1–3 positive nodes, 10-year cumulative incidence for chest wall recurrence of >15% were age <40, peritumoral vessel invasion or 0–7 uninvolved nodes. Age, number of positive nodes and number of uninvolved nodes were significant parameters for each locoregional relapse site. Conclusion: PMRT to the chest wall and supraclavicular fossa is supported in patients with ≥4 positive nodes. With 1–3 positive nodes, chest wall PMRT may be considered in patients aged <40 years, with 0–7 uninvolved nodes or with vascular invasion. The findings do not support PMRT to the dissected axilla.]]> Sat 24 Mar 2018 08:05:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:17752 Sat 24 Mar 2018 07:57:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:21321 n = 4,798) and at the 12-month landmark (n = 4,682) were used for this report. Cohorts of patients with vasomotor symptoms, AMC symptoms, neither, or both were defined at both 3 and 12 months from randomization. Landmark analyses were performed for disease-free survival (DFS) and for breast cancer free interval (BCFI), using regression analysis to estimate hazard ratios (HR) and 95 % confidence intervals (CI). Median follow-up was 7.0 years. Reporting of AMC symptoms was associated with better outcome for both the 3- and 12-month landmark analyses [e.g., 12-month landmark, HR (95 % CI) for DFS = 0.65 (0.49-0.87), and for BCFI = 0.70 (0.49-0.99)]. By contrast, reporting of vasomotor symptoms was less clearly associated with DFS [12-month DFS HR (95 % CI) = 0.82 (0.70-0.96)] and BCFI (12-month DFS HR (95 % CI) = 0.97 (0.80-1.18). Interaction tests indicated no effect of treatment group on associations between symptoms and outcomes. While reporting of AMC symptoms was clearly associated with better DFS and BCFI, the association between vasomotor symptoms and outcome was less clear, especially with respect to breast cancer-related events.]]> Sat 24 Mar 2018 07:52:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/manager/Repository/uon:5531 Sat 24 Mar 2018 07:46:41 AEDT ]]>