https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Ionic liquids accelerate access to N-substituted-1,8-naphthalimides https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17953 85% and the products are isolated by ethanol-mediated precipitation direct from the ionic liquid, requiring no further purification.]]> Thu 01 Aug 2019 17:23:14 AEST ]]> Development of quinone analogues as dynamin GTPase inhibitors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20908 Thu 01 Aug 2019 17:22:27 AEST ]]> Development of 1,8-naphthalimides as clathrin inhibitors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21428 50 ≈ 18 μM). A second library targeting the 4-aminobenzyl moiety was developed, and four analogues displayed comparable activity (26, 27, 28, 34 with IC₅₀ values of 22, 16, 15, and 15 μM respectively) with a further four (24, 25, 32, 33) more active than 18 with IC₅₀ values of 10, 6.9, 12, and 10 μM, respectively. Docking studies rationalized the structure–activity relationship (SAR) with the biological data. 3-Sulfo-N-benzyl-1,8-naphthalimide, potassium salt (25) with an IC50 ≈ 6.9 μM, is the most potent clathrin terminal domain–amphiphysin inhibitor reported to date.]]> Sat 24 Mar 2018 08:05:47 AEDT ]]> Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17945 Sat 24 Mar 2018 07:56:29 AEDT ]]>