/manager/Index ${session.getAttribute("locale")} 5 Modulation of muscle sympathetic bursts by sinusoidal galvanic vestibular stimulation in human subjects /manager/Repository/uon:1063 Sat 24 Mar 2018 08:32:12 AEDT ]]> Absence of short-term vestibular modulation of muscle sympathetic outflow, assessed by brief galvanic vestibular stimulation in awake human subjects /manager/Repository/uon:2491 Sat 24 Mar 2018 08:27:44 AEDT ]]> Neck proprioceptors contribute to the modulation of muscle sympathetic nerve activity to the lower limbs of humans /manager/Repository/uon:20263 Sat 24 Mar 2018 07:59:56 AEDT ]]> Severe hypertension and bradycardia secondary to midodrine overdose /manager/Repository/uon:33115 95 % on FiO2 25 %, and a GS of 8. She was admitted to intensive care and had a normal non-contrast CT brain. She was treated with a glyceryl trinitrate patch (5 mg) and observed for 36 h with subsequent BP reduction to 124/81 mmHg and improved in conscious state. Midodrine and desglymidodrine concentrations were measured with liquid chromatography tandem mass spectrometry and were detected with 2-h post-ingestion at concentrations of 158.4 and 169.7 ng/mL, respectively. The parent drug concentrations rapidly decreased with an elimination of half-life of 1.6 h, and the metabolite initially increased and then decreased. The peak in blood pressure appeared to coincide with peak metabolite concentrations. Midodrine in overdose can potentially cause severe hypertension and reflex bradycardia but given its short half-life treatment with vasodilator agents and supportive care is sufficient.]]> Mon 27 Aug 2018 15:49:46 AEST ]]>