https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24938 Wed 11 Apr 2018 16:25:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23215 Wed 11 Apr 2018 15:05:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28369 Wed 11 Apr 2018 14:08:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27762 in vitro fertilization (IVF) success. Furthermore, reduced expression of HSPA2 from the human sperm proteome leads to an impaired capacity for cumulus matrix dispersal, sperm-egg recognition and fertilization following both IVF and ICSI. In this review, we consider the evidence supporting the role of HSPA2 in sperm function and explore the potential mechanisms by which it is depleted in the spermatozoa of infertile patients. Such information offers novel insights into the molecular mechanisms governing sperm function.]]> Wed 11 Apr 2018 13:54:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21426 Wed 11 Apr 2018 11:46:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25253 Wed 11 Apr 2018 11:30:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27738 Tue 26 Feb 2019 13:24:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40723 Tue 21 Mar 2023 18:42:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39668 n = 124) and a group with seminal abnormalities (SAG, n = 136). Evaluation included complete physical examination, past medical history, habits and lifestyle factors, two complete seminal analysis with sperm functional tests, serum levels of 25-hydroxy-vitamin D₃(25(OH)VD₃), total and free testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone-binding globulin (SHBG), total cholesterol, homeostatic model assessment of insulin resistance (HOMA-IR) index, and karyotype. The mean concentration of 25(OH)VD₃ was significantly lower in the SAG (P < 0.001) and positively correlated with all baseline seminal parameters and total testosterone levels. In addition, serum vitamin D₃ concentration was found to be positively correlated with sperm concentration (β = 2.103; P < 0.001), total number of spermatozoa with progressive motility (β = 2.069; P = 0.003), total number of motile spermatozoa (β = 2.571; P = 0.015), and strict morphology (β = 0.056; P = 0.006), regardless of other variables. This is the first comparative study to address the issue of serum vitamin D₃ content between normozoospermic patients and those with sperm abnormalities. It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality, male reproductive potential, and testosterone levels.]]> Fri 17 Jun 2022 15:25:05 AEST ]]>