/manager/Index ${session.getAttribute("locale")} 5 Infectious complications of biological and small molecule targeted immunomodulatory therapies /manager/Repository/uon:40073 Thu 14 Jul 2022 13:32:13 AEST ]]> Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management /manager/Repository/uon:28396 Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.]]> Sat 24 Mar 2018 07:36:02 AEDT ]]>