/manager/Index ${session.getAttribute("locale")} 5 Steroids from an Australian sponge Psammoclema sp. /manager/Repository/uon:7404 Sat 24 Mar 2018 08:42:43 AEDT ]]> Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi /manager/Repository/uon:17945 Sat 24 Mar 2018 07:56:29 AEDT ]]> Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin /manager/Repository/uon:18787 50) of 42 μM in MCF-7 (breast) cells and 24 μM in A2780 (ovarian) cells and >50 μM in all other cell lines tested. The development of eight focused libraries comprising thirty compounds total identified N-(biphenyl-4-ylmethyl)-1H-pyrrole-2-carboxamide (4l), N-benzyl-4,5-dibromo-1H-pyrrole-2-carboxamide (5a) and N-(biphenyl-4-ylmethyl)-4,5-dibromo-1H-pyrrole-2-carboxamide (5l) as potent inhibitors of cell growth in our panel of cell lines. Of these compounds GI50 values of <5 μM were observed with 4l against HT29 (colon) and SW480 (colon); 5a against HT29; and 5l against HT29, SW480, MCF-7, A431 (skin), Du145 (prostate), BE2-C (neuroblastoma) and MIA (pancreas) cell lines. As a cancer class, colon cancer appears to be more sensitive to the oroidin series of compounds, with analogue 5l being the most active.]]> Sat 24 Mar 2018 07:51:02 AEDT ]]>