/manager/Index ${session.getAttribute("locale")} 5 Effect of immune activation during early gestation or late gestation on inhibitory markers in adult male rats /manager/Repository/uon:45189 In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.]]> Wed 26 Oct 2022 14:26:13 AEDT ]]> Effects of immune activation during early or late gestation on N-methyl-D-aspartate receptor measures in adult rat offspring /manager/Repository/uon:32572 Mon 23 Sep 2019 12:39:53 AEST ]]>