https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Prospective diary evaluation of unexplained abdominal pain and bowel dysfunction: a population-based colonoscopy study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12383 Sat 24 Mar 2018 08:18:00 AEDT ]]> A randomly selected population sample undergoing colonoscopy: prevalence of the irritable bowel syndrome and the impact of selection factors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18602 Sat 24 Mar 2018 08:01:04 AEDT ]]> Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20622 Sat 24 Mar 2018 07:55:47 AEDT ]]> How individuals with the irritable bowel syndrome describe their own symptoms before formal diagnosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26349 Sat 24 Mar 2018 07:35:54 AEDT ]]> Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27132 Brachyspira in colonic biopsies, is uncommon and considered of doubtful significance. We aimed to determine the prevalence of CS in the general population, identify subtle colon pathologies, and evaluate a link with symptoms of IBS. Colonoscopy was performed in 745 subjects (aged 19-70 years, mean age 51 years, 43% male) with biopsies (ileum and 4 colonic sites) from a random population sample, Stockholm, Sweden, who completed a validated questionnaire of gastrointestinal symptoms; IBS was identified by Rome III criteria. CS was identified by histology and immunohistochemistry. In a general population, 17 individuals (2.28%; 95% confidence interval, 1.2%-3.5%) were diagnosed as having CS by histology; 6 (35%) had IBS. CS was always present in the sigmoid colon, but only 14 rectal biopsies. Eosinophils were increased in colon biopsies in CS cases versus controls, in the transverse (P =.02), sigmoid colon (P =.001), and rectum (P =.0005) with subepithelial eosinophil clusters (P =.053). Lymphoid follicles (at any site) were present in 13 CS (P =.0003). There was a 3-fold increased risk of IBS in CS (odds ratio, 3.59; 95% confidence interval, 1.27-10.11; P =.015). Polyps and diverticular disease were similar in CS cases and controls. The prevalence of CS in a general population is 2% and associated with nonconstipating IBS. Colonic eosinophilia with lymphoid follicles may signify the presence of CS.]]> Sat 24 Mar 2018 07:33:02 AEDT ]]>