https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53093 Wed 28 Feb 2024 16:21:51 AEDT ]]> Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29745 9/L vs 0.15×109/L; P<0.0001). Blood eosinophils correlated with both the percentage (ρ=0.535; P<0.0001) and number of sputum eosinophils (ρ=0.473; P<0.0001). Absolute blood eosinophil count was predictive of sputum eosinophilia (area under the curve =0.76, 95% confidence interval [CI] =0.67–0.84; P<0.0001). At a threshold of ≥0.3×10/L (specificity =76%, sensitivity =60%, and positive likelihood ratio =2.5), peripheral blood eosinophil counts enabled identification of the presence or absence of sputum eosinophilia in 71% of the cases. A threshold of ≥0.4×109/L had similar classifying ability but better specificity (91.7%) and higher positive likelihood ratio (3.7). In contrast, ≥0.2×109/L offered a better sensitivity (91.1%) for ruling out sputum eosinophilia. There was a good agreement between two measurements of blood eosinophil count over a median of 28 days (intraclass correlation coefficient =0.8; 95% CI =0.66–0.88; P<0.0001). Conclusion: Peripheral blood eosinophil counts can help identify the presence or absence of sputum eosinophilia in stable COPD patients with a reasonable degree of accuracy.]]> Thu 17 Feb 2022 09:29:13 AEDT ]]> Comorbidity in chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28982 Sat 24 Mar 2018 07:29:26 AEDT ]]> COPD and its comorbidities: impact, measurement and mechanisms https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22677 Sat 24 Mar 2018 07:12:09 AEDT ]]> A sputum 6 gene expression signature predicts inflammatory phenotypes and future exacerbations of COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38377 Fri 10 Sep 2021 12:38:35 AEST ]]> Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30658 Fri 01 Apr 2022 09:24:25 AEDT ]]>