/manager/Index ${session.getAttribute("locale")} 5 Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion /manager/Repository/uon:18276 Wed 11 Apr 2018 12:33:19 AEST ]]> Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism /manager/Repository/uon:17423 TM, was sufficient to abolish BoNT/A-Hc internalization and BoNT/A-induced SNAP25 cleavage in hippocampal neurons. Dyngo-4a also interfered with BoNT/A-Hc internalization into motor nerve terminals. Furthermore, Dyngo-4a afforded protection against BoNT/A-induced paralysis at the rat hemidiaphragm. A significant delay of >30% in the onset of botulism was observed in mice injected with Dyngo-4a. Dynamin inhibition therefore provides a therapeutic avenue for the treatment of botulism and other diseases caused by pathogens sharing dynamin-dependent uptake mechanisms.]]> Sat 24 Mar 2018 08:01:38 AEDT ]]>