/manager/Index ${session.getAttribute("locale")} 5 Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists /manager/Repository/uon:1663 50 : 1 noted. All analogues were screened for their ability to interact with CRH₁ and CRH₂ receptors. In all instances only poor agonistic and/or antagonistic behaviour was noted at CRH₂. However, several compounds were potent and selective CRH₁ antagonists, most notably 13a Ki = 39nM. Additionally we have utilized these data and that recently reported by others to refine our original CRH₁ pharmacophore.]]> Sat 24 Mar 2018 08:30:27 AEDT ]]> Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor /manager/Repository/uon:3031 Sat 24 Mar 2018 08:30:01 AEDT ]]> Combining structure-based drug design and pharmacophores /manager/Repository/uon:295 Sat 24 Mar 2018 07:43:42 AEDT ]]>