https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 A methanol and protic ionic liquid Ugi multicomponent reaction path to cytotoxic a-phenylacetamido amides https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44078 6] and the protic ionic liquid ethanolammonium nitrate (ETAN) failed. Microwave irradiation in EAN facilitated rapid access to three focused libraries, based on the parent isocyanide: cyclohexyl isocyanide, benzyl isocyanide and ethyl isocyanoacetate. Analysis of the structure activity relationship data suggested the presence of a bulky moiety originating from the isocyanide (cyclohexyl and benzyl) enhanced cytotoxicity. Removal of the acetylenic H-atom from the ethanoic acid moiety was detrimental to cytotoxicity. The most active analogues produced, N-(2-cyclohexylamino)-1-(4-methoxyphenyl)-2-oxoethyl-N-(3,5-dimethoxyphenyl)propiolamide, returned average GI₅₀ values of ≤1 μM across the cancer cell lines evaluated. Combined, these data suggest that analogues of this nature are interesting potential anti-cancer development leads.]]> Wed 26 Oct 2022 10:31:27 AEDT ]]> An efficient continuous flow approach to furnish furan-based biaryls https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19862 t-butyl based palladium catalyst CatCart™ FC1032™. Deactivated aryl bromides and activated aryl chlorides were cross-coupled with 5-formyl-2-furanylboronic in the presence of (Bu)₄N⁺OAc⁻ using the bis-triphenylphosphine CatCart™ PdCl₂(PPh₃)₂-DVB. Initial evidence indicates the latter method may serve as a universal approach to conduct Suzuki cross-couplings with the protocol successfully employed in the synthesis of the current gold standard Hedgehog pathway inhibitor LDE225.]]> Wed 11 Apr 2018 17:16:27 AEST ]]> The development of flow chemistry methodologies for the synthesis of potential anti-cancer agents https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21973 Wed 11 Apr 2018 15:31:36 AEST ]]> The expanding utility of continuous flow hydrogenation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28469 Wed 11 Apr 2018 10:47:35 AEST ]]> Expanding the utility of flow hydrogenation - a robust protocol restricting hydrodehalogenation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19846 Sat 24 Mar 2018 07:57:06 AEDT ]]> Discovery of acrylonitrile-based small molecules active against Haemonchus contortus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20974 Sat 24 Mar 2018 07:54:19 AEDT ]]> Synthesis and cytotoxicity of octahydroepoxyisoindole-7-carboxylic acids and norcantharidin-amide hybrids as norcantharidin analogues https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47778 Mon 30 Jan 2023 10:09:52 AEDT ]]>