A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

- Singanayagam, Aran, Glanville, Nicholas, Walton, Ross P., Aniscenko, Julia, Pearson, Rebecca M., Pinkerton, James W., Horvat, Jay C., Hansbro, Philip M., Bartlett, Nathan W., Johnston, Sebastian L.

Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease

- Singanayagam, Aran, Footitt, Joseph, Marczynski, Matthias, Radicioni, Giorgia, Cross, Michael T., Finney, Lydia J., Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria, Zhu, Jie, Aniscenko, Julia, Clarke, Thomas B., Molyneaux, Philip L., Bartlett, Nathan W., Moffatt, Miriam F., Cookson, William O., Wedzicha, Jadwiga, Evans, Christopher M., Boucher, Richard C., Kesimer, Mehmet, Lieleg, Oliver, Mallia, Patrick, Johnston, Sebastian L.

Antiviral immunity is impaired in COPD patients with frequent exacerbations

- Singanayagam, Aran, Bartlett, NW, Mallia, P, Loo, Su-Ling, Reid, Andrew, Footitt, Joseph, Wark, Peter A. B., Grainge, Christopher L., Johnston, Sebastian L., Calderazzo, Maria, Finney, Lydia J., Torralbo, Maria-Belen Trujillo, Bakhsoliani, Eteri, Girkin, Jason, Veerati, Punnam, Pathinayake, Prabuddha S., Nichol, Kristy S.

Beclomethasone has lesser suppressive effects on inflammation and antibacterial immunity than fluticasone or budesonide in experimental infection models

- Kamal, Faisal, Glanville, Nicholas, Xia, Wangmingya, Bakhsoliani, Eteri, Aniscenko, Julia, Bartlett, Nathan W., Edwards, Michael R., Johnston, Sebastian L., Singanayagam, Aran

Blood interferon-a levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients

- Contoli, Marco, Papi, Alberto, Tomassetti, Luca, Rizzo, Paola, Vieceli Dalla Sega, Francesco, Fortini, Francesca, Torsani, Francesca, Morandi, Luca, Ronzoni, Luca, Zucchetti, Ottavio, Pavasini, Rita, Fogagnolo, Alberto, Volta, Carlo Alberto, Bartlett, Nathan W., Johnston, Sebastian L., Spadaro, Savino, Campo, Gianluca

CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection

- Girkin, Jason, Hatchwell, Luke, Foster, Paul, Johnston, Sebastian L., Bartlett, Nathan, Collison, Adam, Mattes, Joerg

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

- Singanayagam, Aran, Glanville, Nicholas, Zhu, Jie, Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria Adelaide, Grainge, Chris, Loo, Su-Ling, Veerati, Punnam Chander, Pathinayake, Prabuddha S., Nichol, Kristy S., Reid, Andrew T., James, Phillip L., Girkin, Jason L., Solari, Roberto, Wark, Peter A. B., Knight, Darryl A., Moffatt, Miriam F., Cookson, William O., Edwards, Michael R., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L., Ching, Yee Man, Marcellini, Andrea, Porter, James D., Toussaint, Marie, Walton, Ross P., Finney, Lydia J., Aniscenko, Julia

Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

- Singanayagam, Aran, Glanville, Nicholas, Cuthbertson, Leah, Bartlett, Nathan W., Finney, Lydia J., Turek, Elena, Bakhsoliani, Eteri, Calderazzo, Maria Adelaide, Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, James, Phillip L., Fenwick, Peter, Kemp, Samuel V., Clarke, Thomas B., Wedzicha, Jadwiga A., Edwards, Michael R., Moffatt, Miriam, Cookson, William O., Mallia, Patrick, Johnston, Sebastian L.

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

- Finney, Lydia J., Glanville, Nicholas, Farne, Hugo, Aniscenko, Julia, Fenwick, Peter, Kemp, Samuel V., Trujillo-Torralbo, Maria-Belen, Loo, Su Ling, Calderazzo, Maria Adelaide, Wedzicha, Jadwiga A., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L., Singanayagam, Aran

Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates T_H2 mediated allergic airways disease and rhinovirus exacerbation

- Cesar de Souza Alves, Caio, Collison, Adam, Ferreira, Ana Paula, Mattes, Joerg, Hatchwell, Luke, Plank, Maximilian, Morten, Matthew, Foster, Paul S., Johnston, Sebastian L., da Costa, Cristiane França, de Almeida, Mauro Vieira, Teixeira, Henrique Couto

miR-122 promotes virus-induced lung disease by targeting SOCS1

- Collison, Adam M., Sokulsky, Leon A., Johnston, Sebastian L., Foster, Paul S., Mattes, Joerg, Kepreotes, Elizabeth, de Siqueira, Ana Pereira, Morten, Matthew, Edwards, Michael R., Walton, Ross P., Bartlett, Nathan W., Yang, Ming, Nguyen, Thi Hiep

Mouse models of rhinovirus infection and airways disease

- Bartlett, Nathan W., Singanayagam, Aran, Johnston, Sebastian L.

Plasmacytoid dendritic cells drive acute asthma exacerbations

- Chairakaki, Aikaterini-Dimitra, Saridaki, Maria-Ioanna, Papadopoulos, Nikolaos G., Johnston, Sebastian L., Andreakos, Evangelos, Pyrillou, Katerina, Mouratis, Marios-Angelos, Koltsida, Ourania, Walton, Ross P., Bartlett, Nathan W., Stavropoulos, Athanasios, Boon, Louis, Rovina, Nikoletta

Rhinovirus-induced CCL17 and CCL22 in asthma exacerbations and differential regulation by STAT6

- Williams, Teresa C., Jackson, David J., Maltby, Steven, Walton, Ross P., Ching, Yee-Mann, Glanville, Nicholas, Singanayagam, Ara, Brewins, Jennifer J., Clarke, Deborah, Hirsman, Aurica G., Loo, Su-Ling, Wei, Lan, Beale, Janine E., Casolari, Paolo, Caramori, Gaetano, Papi, Alberto, Belvisi, Maria, Wark, Peter A. B., Johnston, Sebastian L., Edwards, Michael R., Bartlett, Nathan W.

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

- Collison, Adam, Hatchwell, Luke, Verrills, Nicole, Wark, Peter A. B., Pereira De Siqueira, Ana, Tooze, Melinda, Carpenter, Helen, Don, Anthony S., Morris, Jonathan C., Zimmermann, Nives, Bartlett, Nathan W., Rothenberg, Marc E., Johnston, Sebastian L., Foster, Paul S., Mattes, Joerg

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections: a randomized trial

- Djukanovic, Ratko, Harrison, Tim, Marsden, Richard, Boxall, Christine, Dudley, Sarah, Plagnol, Vincent, Holgate, Stephen T., Monk, Phillip, INTERCIA Study Group,, Johnston, Sebastian L., Gabbay, Flic, Wark, Peter, Thomson, Neil C., Niven, Robert, Singh, Dave, Reddel, Helen K., Davies, Donna E.

The emerging role of microRNAs in regulating immune and inflammatory responses in the lung

- Foster, Paul S., Plank, Maximilian, Mattes, Joerg, Collison, Adam, Tay, Hock L., Kaiko, Gerard E., Li, JingJing, Johnston, Sebastian L., Hansbro, Philip M., Kumar, Rakesh K., Yang, Ming

The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD

- Russell, Kirsty E., Chung, Kian Fan, Starkey, Malcolm R., Hansbro, Philip M., Adcock, Ian M., Wiegman, Coen H., Clarke, Colin J., Durham, Andrew L., Mallia, Patrick, Footit, Joseph, Johnston, Sebastian L., Barnes, Peter J., Hall, Simon R., Simpson, Karen D.

Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia

- Hatchwell, Luke, Collison, Adam, Foster, Paul S., Wark, Peter A. B., Mattes, Joerg, Girkin, Jason, Parsons, Kristy, Li, Junyao, Zhang, Jie, Phipps, Simon, Knight, Darryl, Bartlett, Nathan W., Johnston, Sebastian L.