A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

- Maxwell, Michael J., Thekkedam, Chris, Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B., Mobli, Mehdi, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R.

A constricted opening in Kir channels does not impede potassium conduction

- Black, Katrina A., He, Sitong, Laver, Derek, Robinson, Carol V., Smith, Brian J., Gulbis, Jacqueline M., Jin, Ruitao, Miller, David M., Bolla, Jani R., Clarke, Oliver B., Johnson, Paul, Windley, Monique, Burns, Chirstopher J., Hill, Adam P.

A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.

- Hungate, Eric A., Vora, Sapana R., Rudant, Jéremie, Orsi, Laurent, Clavel, Jacqueline, Milne, Elizabeth, Scott, Rodney J., Pui, Ching-Hon, Cox, Nancy J., Loh, Mignon L., Yang, Jun J., Skol, Andrew D., Gamazon, Eric R., Onel, Kenan, Moriyama, Takaya, Best, Timothy, Hulur, Imge, Lee, Younghee, Evans, Tiffany-Jane, Ellinghaus, Eva, Stanulla, Martin

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

- Martin, Daniel, Degese, Maria S., Thorne, Rick F., Zaida, Moraima, Siegele, Bradford, Cheong, Sok C., Molinolo, Alfredo A., Samuels, Yardena, Tamayo, Pablo, Guan, Kun Liang, Lippman, Scott M., Lyons, J. Guy, Vitale-Cross, Lynn, Gutkind, JS, Iglesias-Bartolome, Ramiro, Valera, Juan Luis Callejas, Wang, Zhiyong, Feng, Xiaodong, Yeerna, Huwate, Vadmal, Vachan, Moroishi, Toshiro

Associations of autozygosity with a broad range of human phenotypes

- Clark, David W., Cocca, M, Collins, FS, Concas, MP, Corley, J, Cugliari, G, Van Dam, RM, Damulina, A, Daneshpour, MS, Day, FR, Delgado, GE, Dhana, K, Doney, ASF, Doerr, M, Doumatey, AP, Dzimiri, N, Ebenesersdottir, SS, Elliott, J, Elliott, P, Ewert, R, Felix, JF, Fischer, K, Freedman, BI, Girotto, G, Goel, A, Gogele, M, Goodarzi, MO, Graff, M, Granot-Hershkovitz, E, Grodstein, F, Guarrera, S, Gudbjartsson, DF, Guity, K, Gunnarsson, B, Guo, Y, Hagenaars, SP, Haiman, CA, Halevy, A, Harris, TB, Hedayati, M, van Heel, DA, Hirata, M, Hofer, I, Hsiung, CA, Huang, J, Hung, Y-J, Ikram, MA, Jagadeesan, A, Jousilahti, P, Kamatani, Y, Kanai, M, Kerrison, ND, Kessler, T, Khaw, K-T, Khor, CC, de Kleijn, DPV, Koh, W-P, Kolcic, I, Kraft, P, Kramer, BK, Kutalik, Z, Kuusisto, J, Langenberg, C, Launer, LJ, Lawlor, DA, Lee, I-T, Lee, W-J, Lerch, MM, Li, L, Liu, J, Loh, M, London, SJ, Loomis, S, Lu, Y, Luan, J, Magi, R, Manichaikul, AW, Manunta, P, Masson, G, Matoba, N, Mei, XW, Meisinger, C, Meitinger, T, Mezzavilla, M, Milani, L, Millwood, IY, Momozawa, Y, Moore, A, Morange, P-E, Moreno-Macias, H, Mori, TA, Morrison, AC, Muka, T, Murakami, Y, Murray, AD, de Mutsert, R, Mychaleckyj, JC, Nalls, MA, Nauck, M, Neville, MJ, Nolte, IM, Ong, KK, Orozco, L, Padmanabhan, S, Palsson, G, Pankow, JS, Pattaro, C, Pattie, A, Polasek, O, Poulter, N, Pramstaller, PP, Quintana-Murci, L, Raikkonen, K, Ralhan, S, Rao, DC, van Rheenen, W, Rich, SS, Ridker, PM, Rietveld, CA, Robino, A, van Rooij, FJA, Ruggiero, D, Saba, Y, Sabanayagam, C, Sabater-Lleal, M, Felicita Sala, C, Salomaa, V, Sandow, K, Schmidt, H, Scott, LJ, Scott, WR, Sedaghati-Khayat, B, Sennblad, B, van Setten, J, Sever, PJ, Sheu, WH-H, Shi, Y, Shrestha, S, Shukla, SR, Sigurdsson, JK, Sikka, TT, Singh, JR, Smith, BH, Stancakova, A, Stanton, A, Starr, JM, Stefansdottir, L, Straker, L, Sulem, P, Sveinbjornsson, G, Swertz, MA, Taylor, AM, Taylor, KD, Terzikhan, N, Tham, Y-C, Thorleifsson, G, Thorsteinsdottir, U, Tillander, A, Tracy, RP, Tusie-Luna, T, Tzoulaki, I, Vaccargiu, S, Vangipurapu, J, Veldink, JH, Vitart, V, Volker, U, Vuoksimaa, E, Wakil, SM, Waldenberger, M, Wander, GS, Wang, YX, Wareham, NJ, Wild, S, Yajnik, CS, Yuan, J-M, Zeng, L, Zhang, L, Zhou, J, Amin, N, Asselbergs, FW, Bakker, SJL, Becker, DM, Lehne, B, Bennett, DA, van den Berg, LH, Berndt, SI, Bharadwaj, D, Bielak, LF, Bochud, M, Boehnke, M, Bouchard, C, Bradfield, JP, Brody, JA, Campbell, A, Carmi, S, Caulfield, MJ, Cesarini, D, Chambers, JC, Chandak, GR, Cheng, C-Y, Ciullo, M, Cornelis, M, Cusi, D, Smith, GD, Deary, IJ, Dorajoo, R, van Duijn, CM, Ellinghaus, D, Erdmann, J, Eriksson, JG, Evangelou, E, Evans, MK, Faul, JD, Feenstra, B, Feitosa, M, Foisy, S, Franke, A, Friedlander, Y, Gasparini, P, Gieger, C, Gonzalez, C, Goyette, P, Grant, SFA, Griffiths, LR, Groop, L, Gudnason, V, Gyllensten, U, Hakonarson, H, Hamsten, A, van der Harst, P, Heng, C-K, Hicks, AA, Hochner, H, Huikuri, H, Hunt, SC, Jaddoe, VWV, De Jager, PL, Johannesson, M, Johansson, A, Jonas, JB, Jukema, JW, Junttila, J, Kaprio, J, Kardia, SLR, Karpe, F, Kumari, M, Laakso, M, van der Laan, SW, Lahti, J, Laudes, M, Lea, RA, Lieb, W, Lumley, T, Martin, NG, Marz, W, Matullo, G, McCarthy, MI, Medland, SE, Merriman, TR, Metspalu, A, Meyer, BF, Mohlke, KL, Montgomery, GW, Mook-Kanamori, D, Munroe, PB, North, KE, Nyholt, DR, O'connell, JR, Ober, C, Oldehinkel, AJ, Palmas, W, Palmer, C, Pasterkamp, GG, Patin, E, Pennell, CE, Perusse, L, Peyser, PA, Pirastu, M, Polderman, TJC, Porteous, DJ, Posthuma, D, Psaty, BM, Rioux, JD, Rivadeneira, F, Rotimi, C, Rotter, JI, Rudan, I, Den Ruijter, HM, Sanghera, DK, Sattar, N, Schmidt, R, Schulze, MB, Schunkert, H, Scott, RA, Shuldiner, AR, Sim, X, Small, N, Smith, JA, Sotoodehnia, N, Tai, E-S, Teumer, A, Timpson, NJ, Toniolo, D, Tregouet, D-A, Tuomi, T, Vollenweider, P, Wang, CA, Weir, DR, Whitfield, JB, Wijmenga, C, Wong, T-Y, Wright, J, Yang, J, Yu, L, Zemel, BS, Zonderman, AB, Perola, M, Magnusson, PKE, Uitterlinden, AG, Kooner, JS, Chasman, DI, Loos, RJF, Franceschini, N, Franke, L, Haley, CS, Hayward, C, Walters, RG, Perry, JRB, Esko, T, Helgason, A, Stefansson, K, Joshi, PK, Kubo, M, Wilson, JF, Okada, Yukinori, Deelen, Patrick, Wang, Carol A., Pennell, Craig E., Orozco, Lorena, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M., Moore, Kristjan H. S., Baumbach, Clemens, Biino, G, Bixley, MJ, Brumat, M, Chai, J-F, Corre, T, Cousminer, DL, Dekker, AM, Eccles, DA, Van Eijk, KR, Mason, Dan, Fuchsberger, C, Gao, H, Germain, M, Gordon, SD, de Haan, HG, Harris, SE, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, IE, Pirastu, Nicola, Jia, Y, Kacprowski, T, Karlsson, T, Kleber, ME, Li, SA, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Gandin, Ilaria, Montasser, ME, van der Most, PJ, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, RB, Priyanka, TDS, Rizzi, F, Salvi, E, Mattsson, Hannele, Sapkota, BR, Shriner, D, Skotte, L, Smart, MC, Smith, AV, van der Spek, A, Spracklen, CN, Strawbridge, RJ, Tajuddin, SM, Trompet, S, Barnes, Catriona L. K., Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, HR, Wootton, RE, Yanek, LR, Yao, J, Yousri, NA, Zhao, W, Lin, Kuang, Adeyemo, AA, Afaq, S, Alberto Aguilar-Salinas, C, Akiyama, M, Albert, ML, Allison, MA, Alver, M, Aung, T, Azizi, F, Bentley, AR, Zhao, Jing Hua, Boeing, H, Boerwinkle, E, Borja, JB, de Borst, GJ, Bottinger, EP, Broer, L, Campbell, H, Chanock, S, Chee, M-L, Chen, G

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

- Feng, Yu Chen, Liu, Xiao Ying, Teng, Liu, Ji, Qiang, Wu, Yongyan, Li, Jin Ming, Gao, Wei, Zhang, Yuan Yuan, La, Ting, Tabatabaee, Hessam, Yan, Xu Guang, Jamaluddin, M. Fairuz B., Zhang, Didi, Guo, Su Tang, Scott, Rodney J., Liu, Tao, Thorne, Rick F., Zhang, Xu Dong, Jin, Lei

Calibration of cognitive tests to address the reliability paradox for decision-conflict tasks

- Kucina, Talira, Wells, Lindsay, Lewis, Ian, de Salas, Kristy, Kohl, Amelia, Palmer, Matthew A., Sauer, James D., Matzke, Dora, Aidman, Eugene, Heathcote, Andrew

Combined burden and functional impact tests for cancer driver discovery using DriverPower

- Shuai, Shimin, Abascal, Federico, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J. Lynn, Amin, Samirkumar B., Scarlett, Christopher J., Frigola, J, Gambacorti-Passerini, C, Garsed, DW, Getz, G, Guo, Q, Gut, IG, Bader, Gary D., Bandopadhayay, Pratiti, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A., Brunak, Søren, Campbell, Peter J.

Controlling piezoresistance in single molecules through the isomerisation of bullvalenes

- Reimers, Jeffrey R., Li, Tiexin, Birvé, André P., Yang, Likun, Aragonès, Albert C., Fallon, Thomas, Kosov, Daniel S., Darwish, Nadim

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

- Singanayagam, Aran, Glanville, Nicholas, Zhu, Jie, Trujillo-Torralbo, Maria-Belen, Calderazzo, Maria Adelaide, Grainge, Chris, Loo, Su-Ling, Veerati, Punnam Chander, Pathinayake, Prabuddha S., Nichol, Kristy S., Reid, Andrew T., James, Phillip L., Girkin, Jason L., Solari, Roberto, Wark, Peter A. B., Knight, Darryl A., Moffatt, Miriam F., Cookson, William O., Edwards, Michael R., Mallia, Patrick, Bartlett, Nathan W., Johnston, Sebastian L., Ching, Yee Man, Marcellini, Andrea, Porter, James D., Toussaint, Marie, Walton, Ross P., Finney, Lydia J., Aniscenko, Julia

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

- Iglesias, Adriana I., Mishra, Aniket, Vitart, Veronique, Bykhovskaya, Yelena, Höhn, René, Springelkamp, Henriët, Cuellar-Partida, Gabriel, Gharahkhani, Puya, Bailey, Jessica N. Cooke, Willoughby, Colin E., Li, Xiaohui, Yazar, Seyhan, Nag, Abhishek, Khawaja, Anthony P., Polašek, Ozren, Siscovick, David, Mitchell, Paul, Tham, Yin Chung, Haines, Jonathan L., Kearns, Lisa S., Hayward, Caroline, Shi, Yuan, van Leeuwen, Elisabeth M., Taylor, Kent D., Wang, Jie Jin, Rochtchina, Elena, Attia, John, Scott, Rodney, Holliday, Elizabeth G., Baird, Paul N., Xie, Jing, Inouye, Michael, Viswanathan, Ananth, Sim, Xueling, Bonnemaijer, Pieter, Rotter, Jerome I., Martin, Nicholas G., Zeller, Tanja, Mills, Richard A., Staffieri, Sandra E., Jonas, Jost B., Schmidtmann, Irene, Boutin, Thibaud, Kang, Jae H., Lucas, Sionne E. M., Wong, Tien Yin, Beutel, Manfred E., Wilson, James F., Allingham, R. Rand, Brilliant, Murray H., Budenz, Donald L., Christen, William G., Fingert, John, Friedman, David S., Gaasterland, Douglas, Gaasterland, Terry, Hauser, Michael A., Kraft, Peter, Lee, Richard K., Lichter, Paul R., Liu, Yutao, Loomis, Stephanie J., Moroi, Sayoko E., Pericak-Vance, Margaret A., Realini, Anthony, Richards, Julia E., Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Weinreb, Robert N., Wollstein, Gadi, Zack, Donald J., Zhang, Kang

Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence

- Semenec, Lucie, Cain, Amy K., Paulsen, Ian T., Dawson, Catherine J., Liu, Qi, Dinh, Hue, Lott, Hannah, Penesyan, Anahit, Maharjan, Ram, Short, Francesca L., Hassan, Karl A.

Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women

- Parkington, Helena C., Stevenson, Janet, Tonta, Mary A., Paul, Jonathan, Butler, Trent, Maiti, Kaushik, Chan, Eng-Cheng, Sheehan, Penelope M., Brennecke, Shaun P., Coleman, Harold A., Smith, Roger

Direct observation of intrinsic room-temperature ferroelectricity in 2D layered CuCrP₂S₆

- Io, Weng Fu, Pang, Sin-Yi, Yi, Jiabao, Hao, Jianhua, Wong, Lok Wing, Zhao, Yuqian, Ding, Ran, Mao, Jianfeng, Zhao, Yifei, Guo, Feng, Yuan, Shuoguo, Zhao, Jiong

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

- Bowerman, Kate L., Rehman, Saima Firdous, Yang, Ian A., Wark, Peter A., Hugenholtz, Philip, Hansbro, Philip M., Vaughan, Annalicia, Lachner, Nancy, Budden, Kurtis F., Kim, Richard Y., Wood, David L. A., Gellatly, Shaan L., Shukla, Shakti D., Wood, Lisa G.

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

- Trastulla, Lucia, Dolgalev, Georgii, Domenici, Enrico, Henskens, Frans A., Loughland, Carmel M., Michie, Patricia T., Schall, Ulrich, Scott, Ronald J., Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Moser, Sylvain, Bene, Judit, Bergen, SE, Bevilacqua, E, Bigdeli, TB, Black, DW, Blackwood, DHR, Borglum, AD, Bramon, E, Bruggeman, R, Buccola, NG, Jiménez-Barrón, Laura T., Buckner, RL, Bulik-Sullivan, B, Buxbaum, JD, Byerley, W, Cahn, W, Cai, G, Campion, D, Cantor, RM, Carr, VJ, Carrera, N, Andlauer, Till F. M., Catts, SV, Chambert, KD, Chan, RCK, Chen, EYH, Chen, RYL, Cheng, W, Cheung, EFC, Chong, SA, Cichon, S, Cloninger, CR, von Scheidt, Moritz, Cohen, D, Cohen, N, Collier, DA, Cormican, P, Craddock, N, Crowley, JJ, Daly, MJ, Darvasi, A, Davidson, M, Davis, KL, Ruderfer, Douglas M., Degenhardt, F, Del Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Ripke, Stephan, Ehrenreich, H, Eichhammer, P, Eriksson, J, Escott-Price, V, Esko, T, Essioux, L, Farh, KH, Farrell, MS, Frank, J, Franke, L, McQuillin, Andrew, Freedman, R, Freimer, NB, Friedman, JI, Fromer, M, Gejman, PV, Genovese, G, Georgieva, L, Giegling, I, Gill, M, Giusti-Rodriguez, P, Stahl, Eli A., Godard, S, Goldstein, JI, Gopal, S, Gratten, J, Gurling, H, de Haan, L, Hammer, C, Hamshere, ML, Hansen, M, Hansen, T

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

- To, Eunice E., Vlahos, Ross, Starkey, Malcolm R., van der Sluis, Renee, Lewin, Sharon R., Bozinovski, Steven, O'Neill, Luke A. J., Quach, Tim, Porter, Christopher J. H., Brooks, Doug A., O'Leary, John J., Selemidis, Stavros, Luong, Raymond, Halls, Michelle L., Reading, Patrick C., King, Paul T., Chan, Christopher, Drummond, Grant R., Sobey, Christopher G., Broughton, Brad R. S.

Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

- Ibn Sina, Abu Ali, Carrascosa, Laura G., Korbie, Darren, Trau, Matt, Liang, Ziyu, Grewal, Yadveer S., Wardiana, Andri, Shiddiky, Muhammad J. A., Gardiner, Robert A., Samaratunga, Hemamali, Gandhi, Maher K., Scott, Rodney J.

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

- Budu-Aggrey, Ashley, Kilanowski, Anna, Nelis, Mari, .,, Tanaka, Nao, Brumpton, Ben M., Thomas, Laurent F., Sole-Navais, Pol, Flatley, Christopher, Espuela-Ortiz, Antonio, Herrera-Luis, Esther, Lominchar, Jesus V. T., Bork-Jensen, Jette, Sobczyk, Maria K., Wang, Carol A., Pennell, Craig E., 23andMe Research Team,, Shringarpure, Suyash S., Mitchell, Ruth, Reis, Kadri, Reigo, Anu, Estonian Biobank Research Team,, Mägi, Reedik

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

- Thorburn, Alison N., McKenzie, Craig I., Chevalier, Nina, Tan, Jian K., Marinõ, Eliana, Moore, Rob J., Wong, Lee, McConville, Malcolm J., Tull, Dedreia L., Wood, Lisa G., Murphy, Vanessa E., Mattes, Joerg, Shen, Sj, Gibson, Peter G., MacKay, Charles R., Stanley, Dragana, MacIa, Laurence, Mason, Linda J., Roberts, Laura K., Wong, Connie H. Y., Shim, Raymond, Robert, Remy