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The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene

Luminal Ca²⁺ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca²⁺ via cytoplasmic Ca²⁺ sites

Ca²⁺ stores regulate ryanodine receptor Ca²⁺ release channels via luminal and cytosolic Ca²⁺ sites

The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca²⁺ binding site

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