Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease
- Creator: Singanayagam, Aran , Footitt, Joseph , Marczynski, Matthias , Radicioni, Giorgia , Cross, Michael T. , Finney, Lydia J. , Trujillo-Torralbo, Maria-Belen , Calderazzo, Maria , Zhu, Jie , Aniscenko, Julia , Clarke, Thomas B. , Molyneaux, Philip L. , Bartlett, Nathan W. , Moffatt, Miriam F. , Cookson, William O. , Wedzicha, Jadwiga , Evans, Christopher M. , Boucher, Richard C. , Kesimer, Mehmet , Lieleg, Oliver , Mallia, Patrick , Johnston, Sebastian L.
- Resource Type: journal article
- Date: 2022
Blood interferon-a levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients
- Creator: Contoli, Marco , Papi, Alberto , Tomassetti, Luca , Rizzo, Paola , Vieceli Dalla Sega, Francesco , Fortini, Francesca , Torsani, Francesca , Morandi, Luca , Ronzoni, Luca , Zucchetti, Ottavio , Pavasini, Rita , Fogagnolo, Alberto , Volta, Carlo Alberto , Bartlett, Nathan W. , Johnston, Sebastian L. , Spadaro, Savino , Campo, Gianluca
- Resource Type: journal article
- Date: 2021
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
- Creator: Finney, Lydia J. , Glanville, Nicholas , Farne, Hugo , Aniscenko, Julia , Fenwick, Peter , Kemp, Samuel V. , Trujillo-Torralbo, Maria-Belen , Loo, Su Ling , Calderazzo, Maria Adelaide , Wedzicha, Jadwiga A. , Mallia, Patrick , Bartlett, Nathan W. , Johnston, Sebastian L. , Singanayagam, Aran
- Resource Type: journal article
- Date: 2021
miR-122 promotes virus-induced lung disease by targeting SOCS1
- Creator: Collison, Adam M. , Sokulsky, Leon A. , Johnston, Sebastian L. , Foster, Paul S. , Mattes, Joerg , Kepreotes, Elizabeth , de Siqueira, Ana Pereira , Morten, Matthew , Edwards, Michael R. , Walton, Ross P. , Bartlett, Nathan W. , Yang, Ming , Nguyen, Thi Hiep
- Resource Type: journal article
- Date: 2021
Rhinovirus-induced CCL17 and CCL22 in asthma exacerbations and differential regulation by STAT6
- Creator: Williams, Teresa C. , Jackson, David J. , Maltby, Steven , Walton, Ross P. , Ching, Yee-Mann , Glanville, Nicholas , Singanayagam, Ara , Brewins, Jennifer J. , Clarke, Deborah , Hirsman, Aurica G. , Loo, Su-Ling , Wei, Lan , Beale, Janine E. , Casolari, Paolo , Caramori, Gaetano , Papi, Alberto , Belvisi, Maria , Wark, Peter A. B. , Johnston, Sebastian L. , Edwards, Michael R. , Bartlett, Nathan W.
- Resource Type: journal article
- Date: 2021
Beclomethasone has lesser suppressive effects on inflammation and antibacterial immunity than fluticasone or budesonide in experimental infection models
- Creator: Kamal, Faisal , Glanville, Nicholas , Xia, Wangmingya , Bakhsoliani, Eteri , Aniscenko, Julia , Bartlett, Nathan W. , Edwards, Michael R. , Johnston, Sebastian L. , Singanayagam, Aran
- Resource Type: journal article
- Date: 2020
Antiviral immunity is impaired in COPD patients with frequent exacerbations
- Creator: Singanayagam, Aran , Bartlett, NW , Mallia, P , Loo, Su-Ling , Reid, Andrew , Footitt, Joseph , Wark, Peter A. B. , Grainge, Christopher L. , Johnston, Sebastian L. , Calderazzo, Maria , Finney, Lydia J. , Torralbo, Maria-Belen Trujillo , Bakhsoliani, Eteri , Girkin, Jason , Veerati, Punnam , Pathinayake, Prabuddha S. , Nichol, Kristy S.
- Resource Type: journal article
- Date: 2019
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
- Creator: Singanayagam, Aran , Glanville, Nicholas , Cuthbertson, Leah , Bartlett, Nathan W. , Finney, Lydia J. , Turek, Elena , Bakhsoliani, Eteri , Calderazzo, Maria Adelaide , Trujillo-Torralbo, Maria-Belen , Footitt, Joseph , James, Phillip L. , Fenwick, Peter , Kemp, Samuel V. , Clarke, Thomas B. , Wedzicha, Jadwiga A. , Edwards, Michael R. , Moffatt, Miriam , Cookson, William O. , Mallia, Patrick , Johnston, Sebastian L.
- Resource Type: journal article
- Date: 2019
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
- Creator: Singanayagam, Aran , Glanville, Nicholas , Zhu, Jie , Trujillo-Torralbo, Maria-Belen , Calderazzo, Maria Adelaide , Grainge, Chris , Loo, Su-Ling , Veerati, Punnam Chander , Pathinayake, Prabuddha S. , Nichol, Kristy S. , Reid, Andrew T. , James, Phillip L. , Girkin, Jason L. , Solari, Roberto , Wark, Peter A. B. , Knight, Darryl A. , Moffatt, Miriam F. , Cookson, William O. , Edwards, Michael R. , Mallia, Patrick , Bartlett, Nathan W. , Johnston, Sebastian L. , Ching, Yee Man , Marcellini, Andrea , Porter, James D. , Toussaint, Marie , Walton, Ross P. , Finney, Lydia J. , Aniscenko, Julia
- Resource Type: journal article
- Date: 2018
Plasmacytoid dendritic cells drive acute asthma exacerbations
- Creator: Chairakaki, Aikaterini-Dimitra , Saridaki, Maria-Ioanna , Papadopoulos, Nikolaos G. , Johnston, Sebastian L. , Andreakos, Evangelos , Pyrillou, Katerina , Mouratis, Marios-Angelos , Koltsida, Ourania , Walton, Ross P. , Bartlett, Nathan W. , Stavropoulos, Athanasios , Boon, Louis , Rovina, Nikoletta
- Resource Type: journal article
- Date: 2018
The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD
- Creator: Russell, Kirsty E. , Chung, Kian Fan , Starkey, Malcolm R. , Hansbro, Philip M. , Adcock, Ian M. , Wiegman, Coen H. , Clarke, Colin J. , Durham, Andrew L. , Mallia, Patrick , Footit, Joseph , Johnston, Sebastian L. , Barnes, Peter J. , Hall, Simon R. , Simpson, Karen D.
- Resource Type: journal article
- Date: 2016
A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD
- Creator: Singanayagam, Aran , Glanville, Nicholas , Walton, Ross P. , Aniscenko, Julia , Pearson, Rebecca M. , Pinkerton, James W. , Horvat, Jay C. , Hansbro, Philip M. , Bartlett, Nathan W. , Johnston, Sebastian L.
- Resource Type: journal article
- Date: 2015
CCL7 and IRF-7 mediate hallmark inflammatory and IFN responses following rhinovirus 1B infection
- Creator: Girkin, Jason , Hatchwell, Luke , Foster, Paul , Johnston, Sebastian L. , Bartlett, Nathan , Collison, Adam , Mattes, Joerg
- Resource Type: journal article
- Date: 2015
Mouse models of rhinovirus infection and airways disease
- Creator: Bartlett, Nathan W. , Singanayagam, Aran , Johnston, Sebastian L.
- Resource Type: book chapter
- Date: 2015
Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia
- Creator: Hatchwell, Luke , Collison, Adam , Foster, Paul S. , Wark, Peter A. B. , Mattes, Joerg , Girkin, Jason , Parsons, Kristy , Li, Junyao , Zhang, Jie , Phipps, Simon , Knight, Darryl , Bartlett, Nathan W. , Johnston, Sebastian L.
- Resource Type: journal article
- Date: 2015
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections: a randomized trial
- Creator: Djukanovic, Ratko , Harrison, Tim , Marsden, Richard , Boxall, Christine , Dudley, Sarah , Plagnol, Vincent , Holgate, Stephen T. , Monk, Phillip , INTERCIA Study Group, , Johnston, Sebastian L. , Gabbay, Flic , Wark, Peter , Thomson, Neil C. , Niven, Robert , Singh, Dave , Reddel, Helen K. , Davies, Donna E.
- Resource Type: journal article
- Date: 2014
Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation
- Creator: Cesar de Souza Alves, Caio , Collison, Adam , Ferreira, Ana Paula , Mattes, Joerg , Hatchwell, Luke , Plank, Maximilian , Morten, Matthew , Foster, Paul S. , Johnston, Sebastian L. , da Costa, Cristiane França , de Almeida, Mauro Vieira , Teixeira, Henrique Couto
- Resource Type: journal article
- Date: 2013
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity
- Creator: Collison, Adam , Hatchwell, Luke , Verrills, Nicole , Wark, Peter A. B. , Pereira De Siqueira, Ana , Tooze, Melinda , Carpenter, Helen , Don, Anthony S. , Morris, Jonathan C. , Zimmermann, Nives , Bartlett, Nathan W. , Rothenberg, Marc E. , Johnston, Sebastian L. , Foster, Paul S. , Mattes, Joerg
- Resource Type: journal article
- Date: 2013
The emerging role of microRNAs in regulating immune and inflammatory responses in the lung
- Creator: Foster, Paul S. , Plank, Maximilian , Mattes, Joerg , Collison, Adam , Tay, Hock L. , Kaiko, Gerard E. , Li, JingJing , Johnston, Sebastian L. , Hansbro, Philip M. , Kumar, Rakesh K. , Yang, Ming
- Resource Type: journal article
- Date: 2013