17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

- Adib-Samii, Poneh, Rost, Natalia, Gschwendtner, Andreas, Malik, Rainer, Richie, Alexa, Gamble, Dale, Segal, Helen, Parati, Eugenio A., Ciusani, Emilio, Holliday, Elizabeth G., Maguire, Jane, Wardlaw, Joanna, Traylor, Matthew, Worrall, Bradford, Bis, Joshua, Wiggins, Kerri L., Longstreth, Will, Kittner, Steve J., Cheng, Yu-Ching, Mosley, Thomas, Falcone, Guido J., Furie, Karen L., Leiva-Salinas, Carlos, Devan, William, Lau, Benison C., Saleem Khan, Muhammed, Australian Stroke Genetics Collaborative, Wellcome Trust Case-Control Consortium-2, METASTROKE, Sharma, Pankaj, Fornage, Miriam, Mitchell, Braxton D., Psaty, Bruce M., Sudlow, Cathie, Biffi, Alessandro, Levi, Christopher, Boncoraglio, Giorgio B., Rothwell, Peter M., Meschia, James, Dichgans, Martin, Rosand, Jonathan, Markus, Hugh S., Lanfranconi, Silvia, Fitzpatrick, Kaitlin, Bevan, Steve, Kanakis, Allison, Valant, Valerie

A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

- Traylor, Matthew, Mäkelä, Kari-Matti, Malik, Rainer, Sudlow, Cathie, Bevan, Steve, Raitoharju, Emma, Oksala, Niku, Thijs, Vincent, Lemmens, Robin, Lindgren, Arne, Slowik, Agnieszka, Kilarski, Laura L., Maguire, Jane M., Walters, Matthew, Algra, Ale, Sharma, Pankaj, Attia, John R., Boncoraglio, Giorgio B., Rothwell, Peter M., de Bakker, Paul I. W., Bis, Joshua C., Saleheen, Danish, Holliday, ELizabeth G., Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Meschia, James F., Levi, Christopher, Dichgans, Martin, Lehtimäki, Terho, Lewis, Cathryn M., Markus, Hugh S., Devan, William J., Nalls, Mike A., Wiggins, Kerri L., Zhao, Wei, Cheng, Yu-Ching, Achterberg, Sefanja

Association of MTHFR C677T genotype with ischemic stroke is confined to cerebral small vessel disease subtype

- Rutten-Jacobs, Loes C. A., Traylor, Matthew, Levi, Christopher, Rost, Natalia S., Rosand, Jonathan, Hassan, Ahamad, Bevan, Steve, Markus, Hugh S., Adib-Samii, Ppneh, Thijs, Vincent, Sudlow, Cathie, Rothwell, Peter M., Boncoraglio, Giorgio, Dichgans, Martin, Meschia, James, Maguire, Jane

Common NOTCH3 variants and cerebral small-vessel disease

- Rutten-Jacobs, Loes C. A., Traylor, Matthew, Levi, Christopher, Rost, Natalia S., Rosand, Jonathan, Hassan, Ahamad, Markus, Hugh S., Adib-Samii, Poneh, Thijs, Vincent, Sudlow, Cathie, Rothwell, Peter M., Boncoraglio, Giorgio, Dichgans, Martin, Bevan, Steve, Meschia, James

Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease

- Rannikmäe, Kristiina, Davies, Gail, Deka, Ranjan, Woo, Jessica G., Martin, Lisa J., Jimenez-Conde, Jordi, Selim, Magdy, Brown, Devin L., Silliman, Scott L., Kidwell, Chelsea S., Montaner, Joan, Langefeld, Carl D., Thomson, Pippa A., Holliday, Elizabeth G., Levi, Christopher R., Attia, John, Rothwell, Peter M., Poole, Deborah L., Bevan, Steve, Devan, William J., Falcone, Guido J., Traylor, Matthew, Anderson, Christopher D., Battey, Thomas W. K., Radmanesh, Farid

Differences in common genetic predisposition to ischemic stroke by age and sex

- Traylor, Matthew, Rutten-Jacobs, Loes C. A., Dichgans, Martin, Levi, Chris, Lewis, Cathryn M., Markus, Hugh S., Holliday, Elizabeth G., Malik, Rainer, Sudlow, Cathie, Rothwell, Peter M., Maguire, Jane M., Koblar, Simon A., Bevan, Steve, Boncoraglio, Giorgio

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

- Chauhan, Ganesh, Adams, Hieab H. H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheung, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, G. D., Kjartansson, O., Guðnason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N, Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C.Y., Wong, T. Y., Ikram, M. K., van der Lee, S. J., Amin, N., Chouraki, V., Destefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., Decarli, C., Wardlaw, J. M., Del C. Valdés Hernández, M., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Maniega, S. M., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H. W., Lemmens, R., Brodaty, H., Wright, MJ., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., van der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., van der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., von Sarnowski, B., Völker, U., Levi, Christopher, Jimenez-Conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Mechia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Asselbergs, F. R., Srikanth, V., Thomson, R., McWhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-Jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T., Debette, S.

Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke

- Adib-Samii, Poneh, Devan, William, Rothwell, Peter M., Sudlow, Cathie, Boncoraglio, Giorgio B., Meschia, James F., Levi, Chris, Dichgans, Martin, Bevan, Steve, Rosand, Jonathan, Rost, Natalia S., Markus, Hugh S., Traylor, Matthew, Lanfranconi, Silvia, Zhang, Cathy R., Cloonan, Lisa, Falcone, Guido J., Radmanesh, Farid, Fitzpatrick, Kaitlin, Kanakis, Allison

Genetic associations with white matter hyperintensities confer risk of lacunar stroke

- Traylor, Matthew, Rutten-Jacobs, Loes C. A., Dichgans, Martin, Markus, Hugh S., Thijs, Vincent, Holliday, Elizabeth G., Levi, Chris, Bevan, Steve, Malik, Rainer, Boncoraglio, Giorgio, Sudlow, Cathie, Rothwell, Peter M.

Genetic overlap between diagnostic subtypes of ischemic stroke

- Holliday, Elizabeth G., Traylor, Matthew, Boncoraglio, Giorgio B., Clarke, Robert, Cole, John W., Fornage, Myriam, Furie, Karen L., Ikram, M. Arfan, Jannes, Jim, Kittner, Steven J., Lincz, Lisa F., Maguire, Jane M., Malik, Rainer, Oldmeadow, Christopher, Scott, Rodney J., Levi, Christopher, Attia, John, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C., Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C., Boerwinkle, Eric

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

- Traylor, Matthew, Farrall, Martin, Thorsteinsdottir, Unnur, Nalls, Mike A., Longstreth, W. T., Wiggins, Kerri L., Yadav, Sunaina, Parati, Eugenio A., Destefano, Anita L., Worrall, Bradford B., Kittner, Steven J., Khan, Muhammad Saleem, Holliday, Elizabeth G., Reiner, Alex P., Helgadottir, Anna, Achterberg, Sefanja, Fernandez-Cadenas, Israel, Abboud, Sherine, Schmidt, Reinhold, Walters, Matthew, Chen, Wei-Min, Ringelstein, E. Bernd, O'Donnell, Martin, Sudlow, Cathie, Ho, Weang Kee, Pera, Joanna, Lemmens, Robin, Norrving, Bo, Higgins, Peter, Benn, Marianne, Sale, Michele, Kuhlenbaumer, Gregor, Doney, Alexander S. F., Vicente, Astrid M., Hopewell, Jemma C., Delavaran, Hossein, Algra, Ale, Davies, Gail, Oliveira, Sophia A., Palmer, Colin N. A., Deary, Ian, Schmidt, Helena, Pandolfo, Massimo, Montaner, Joan, Carty, Cara, Cheng, Yu-Ching, De Bakker, Paul I. W., Kostulas, Konstantinos, Ferro, Jose M., Van Zuydam, Natalie R., Valdimarsson, Einar, Nordestgaard, Berge G., Lindgren, Anne, Thijs, Vincent, Slowik, Agnieszka, Saleheen, Danish, Fornage, Myriam, Paré, Guillaume, Berger, Klaus, Thorleifsson, Gudmar, Astc, W., Hofman, Albert, Mosley, Thomas H., Mitchell, Branxton D., Furie, Karen, Clarke, Robert, Levi, Christopher, Arfan Ikram, M,, Seshadri, Sudha, Gschwendtner, Andreas, Boncoraglio, Giorgio B., Sharma, Pankaj, Bis, Joshua C., Gretarsdottir, Solveig, Psaty, Bruce M., Rothwell, Peter M., Rosand, Jonathan, Meschia, James F., Malik, Rainer, Stefansson, Kari, Dichgans, Martin, Markus, Hugh S., Bevan, Steve

Genetic variation at 16q24.2 is associated with small vessel stroke

- Traylor, Matthew, Malik, Rainer, Yet, Idil, Spector, Tim D., Bell, Jordana T., Hannon, Ellis, Mill, Jonathan, Chauhan, Ganesh, Debette, Stephanie, Bis, Joshua C., Longstreth, W. T., Ikram, M. Arfan, Nalls, Mike A., Levi, Chris, Cotlarciuc, Iona, Radmanesh, Farid, Thorleifsson, Gudmar, Hanscombe, Ken B., Langefeld, Carl, Saleheen, Danish, Rost, Natalia S.

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

- Keaton, Jacob M., Kamali, Zoha, Young, William J., Lehtimäki, T, Raitakari, OT, Johnson, AD, Newton-Cheh, C, Brown, MJ, Dominiczak, AF, Sever, PJ, Poulter, N, Chambers, JC, Elosua, R, Traylor, Matthew, Siscovick, D, Esko, T, Metspalu, A, Strawbridge, RJ, Laakso, M, Hamsten, A, Hottenga, J-J, de Geus, E, Morris, AD, Palmer, CNA, Giri, Ayush, Nolte, IM, Milaneschi, Y, Marten, J, Wright, A, Zeggini, E, Howson, JMM, O'Donnell, CJ, Spector, T, Nalls, MA, Simonsick, EM, Zheng, Zhili, Liu, Y, van Duijn, CM, Butterworth, AS, Danesh, JN, Menni, C, Wareham, NJ, Khaw, K-T, Sun, YV, Wilson, PWF, Cho, K, Zeng, Jian, Visscher, PM, Denny, JC, Million Veteran Program,, Lifelines Cohort Study,, CHARGE consortium,, ICBP Consortium,, Levy, D, Edwards, TL, Munroe, PB, Snieder, H, Chasman, Daniel I., Warren, HR, Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Xie, Tian, Attia, John R., Attia, JR, Morrison, AC, Loos, RJF, Kristiansson, K, Schmidt, R, Hicks, AA, Pramstaller, PP, Nelson, CP, Samani, NJ, Vaez, Ahmad, Risch, L, Gyllensten, U, Melander, O, Riese, H, Wilson, JF, Campbell, H, Rich, SS, Psaty, BM, Lu, Y, Rotter, JI, Williams, Ariel, Guo, X, Rice, KM, Vollenweider, P, Sundström, J, Langenberg, C, Tobin, MD, Giedraitis, V, Luan, J, Tuomilehto, J, Kutalik, Z, Goleva, Slavina B., Ripatti, S, Salomaa, V, Girotto, G, Trompet, S, Jukema, JW, van der Harst, P, Ridker, PM, Giulianini, F, Vitart, V, Goel, A, Ani, Alireza, Watkins, H, Harris, SE, Deary, IJ, van der Most, PJ, Oldehinkel, AJ, Keavney, BD, Hayward, C, Campbell, A, Boehnke, M, Scott, LJ, Evangelou, Evangelos, Boutin, T, Mamasoula, C, Järvelin, M-R, Peters, A, Gieger, C, Lakatta, EG, Cucca, F, Hui, J, Knekt, P, Enroth, S, Hellwege, Jacklyn N., De Borst, MH, Polašek, O, Concas, MP, Catamo, E, Cocca, M, Li-Gao, R, Hofer, E, Schmidt, H, Spedicati, B, Waldenberger, M, Yengo, Loic, Strachan, DP, Laan, M, Teumer, A, Dörr, M, Gudnason, V, Cook, JP, Ruggiero, D, Kolcic, I, Boerwinkle, E, Traglia, M

Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2

- Cheng, Yu-Ching, Stanne, Tara M., Cole, John W., O'Connell, Jeffrey R., Danesh, John, Rasheed, Asif, Zhao, Wei, Engelter, Stefan, Grond-Ginsbach, Caspar, Kamatani, Yoichiro, Lathrop, Mark, Leys, Didier, Giese, Anne-Katrin, Levi, Christopher, Ho, Weang Kee, Traylor, Matthew, Amouyel, Philippe, Holliday, Elizabeth G., Malik, Rainer, Xu, Huichun, Kittner, Steven J.

Genome-wide association meta-analysis of functional outcome after ischemic stroke

- Söderholm, Martin, Pedersen, Annie, Jood, Katarina, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher, Mitchell, Braxton D., Norrving, Bo, Rannikmäe, Kristiina, Rost, Natalia S., Rosand, Jonathan, Rothwell, Peter M., Lorentzen, Erik, Scott, Rodney, Strbian, Daniel, Sturm, Jonathan W., Sudlow, Cathie, Traylor, Matthew, Thijs, Vincent, Tatlisumak, Turgut, Woo, Daniel, Worrall, Bradford B., Maguire, Jane M., Stanne, Tara M., Lindgren, Arne, Jern, Christina, Bevan, Steve, Olsson, Maja, Cole, John W., Fernandez-Cadenas, Israel, Hankey, Graeme J., Jimenez-Conde, Jordi

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

- Bellenguez, Céline, Bevan, Steve, Band, Gavin, Syme, Paul D., Malik, Rainer, Pera, Joanna, Norrving, Bo, Lemmens, Robin, Freeman, Colin, Schanz, Renata, James, Tom, Poole, Deborah, Gschwendtner, Andreas, Murphy, Lee, Segal, Helen, Cortellini, Lynelle, Cheng, Yu-Ching, Woo, Daniel, Nalls, Michael A., Müller-Myhsok, Bertram, Meisinger, Christa, Seedorf, Udo, Ross-Adams, Helen, Spencer, Chris C. A., Boonen, Steven, Wloch-Kopec, Dorota, Valant, Valerie, Slark, Julia, Furie, Karen, Delavaran, Hossein, Langford, Cordelia, Deloukas, Panos, Edkins, Sarah, Hunt, Sarah, Burgess, Annette I., Gray, Emma, Dronov, Serge, Peltonen, Leena, Gretarsdottir, Solveig, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Boncoraglio, Giorgio B., Parati, Eugenio A., Attia, John, Pirinen, Matti, Holliday, Elizabeth, Levi, Chris, Franzosi, Maria-Grazia, Goel, Anuj, Helgadottir, Anna, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Jackson, Caroline A., Duncanson, Audrey, Jankowski, Janusz, Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Viswanathan, Ananth C., Wood, Nicholas W., Traylor, Matthew, Worrall, Bradford B., Kittner, Steven J., Mitchell, Braxton D., Kissela, Brett, Meschia, James F., Thijs, Vincent, Lindgren, Arne, Macleod, Mary Joan, Slowik, Agnieszka, Walters, Matthew, Strange, Amy, Rosand, Jonathan, Sharma, Pankaj, Farrall, Martin, Sudlow, Cathie L. M., Rothwell, Peter M., Dichgans, Martin, Donnelly, Peter, Markus, Hugh S., Su, Zhan

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke

- Traylor, Matthew, Zhang, Cathy R., Fitzpatrick, Kaitlin, Kanakis, Allison, Barrick, Thomas R., Moynihan, Barry, Lewis, Cathryn M., Boncoraglio, Giorgio B., Lemmens, Robin, Thijs, Vincent, Sudlow, Cathie, Wardlaw, Joanna, Adib-Samii, Poneh, Levi, Christopher, Bevan, Steve, Devan, William J., Parsons, Owen E., Lanfranconi, Silvia, Gregory, Sarah, Cloonan, Lisa, Falcone, Guido J., Radmanesh, Fadrid

Ischemic stroke is associated with the ABO locus: the EuroCLOT Study

- Williams, Frances M. K., Carter, Angela M., Sudlow, Cathie, Farrall, Martin, Silander, Kaisa, Kaunisto, Mari, Wagner, Peter, Saarela, Olli, Kuulasmaa, Kari, Virtamo, Jarmo, Salomaa, Veikko, Amouyel, Philippe, Hysi, Pirro G., Bis, Joshua C., Levi, Christopher, Attia, John, Holliday, Elizabeth G., Scott, Rodney J., Surdulescu, Gabriela, Hodgkiss, Dylan, Soranzo, Nicole, Traylor, Matthew, Bevan, Steve, Dichgans, Martin, Rothwell, Peter M. W.

Low-frequency and common genetic variation in ischemic stroke: the METASTROKE collaboration

- Malik, Rainer, Traylor, Matthew, Battey, Thomas W. K., Berger, Klaus, Boncoraglio, Giorgio B., Chauhan, Ganesh, Cheng, Yu-Ching, Chen, Wei-Min, Clarke, Robert, Cotlarciuc, Ioana, Debette, Stephanie, Falcone, Guido J., Pulit, Sara L., Levi, Christopher R., Bevan, Steve, Hopewell, Jemma C., Holliday, Elizabeth G., Zhao, Wei, Abrantes, Patricia, Amouyel, Philippe, Attia, John R.

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

- Kilarski, Laura L., Achterberg, Sefanja, Walters, Matthew, Worrall, Bradford B., Sale, Michele M., Algra, Ale, Kappelle, L. Jaap, Wijmenga, Cisca, Norrving, Bo, Sandling, Johanna K., Röennblom, Lars, Goris, An, Devan, William J., Franke, Andre, Sudlow, Cathie, Rothwell, Peter M., Levi, Christopher, Holliday, Elizabeth G., Fornage, Myriam, Psaty, Bruce, Gretarsdottir, Solveig, Thorsteinsdottir, Unnar, Seshadri, Sudha, Traylor, Matthew, Mitchell, Braxton D., Kittner, Steven, Clarke, Robert, Hopewell, Jemma C., Bis, Joshua C., Boncoraglio, Giorgio B., Meschia, James, Ikram, M. Arfan, Hansen, Bjorn M., Montaner, Joan, Malik, Rainer, Thorleifsson, Gudmar, Stefanson, Kari, Rosand, Jonathan, de Bakker, Paul I. W., Farrall, Martin, Dichgans, Martin, Markus, Hugh S., Bevan, Steve, Lindgren, Arne, Pare, Guillame, Sharma, Pankaj, Slowik, Agniescka, Thijs, Vincent