Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Creator: Keaton, Jacob M. , Kamali, Zoha , Young, William J. , Lehtimäki, T , Raitakari, OT , Johnson, AD , Newton-Cheh, C , Brown, MJ , Dominiczak, AF , Sever, PJ , Poulter, N , Chambers, JC , Elosua, R , Traylor, Matthew , Siscovick, D , Esko, T , Metspalu, A , Strawbridge, RJ , Laakso, M , Hamsten, A , Hottenga, J-J , de Geus, E , Morris, AD , Palmer, CNA , Giri, Ayush , Nolte, IM , Milaneschi, Y , Marten, J , Wright, A , Zeggini, E , Howson, JMM , O'Donnell, CJ , Spector, T , Nalls, MA , Simonsick, EM , Zheng, Zhili , Liu, Y , van Duijn, CM , Butterworth, AS , Danesh, JN , Menni, C , Wareham, NJ , Khaw, K-T , Sun, YV , Wilson, PWF , Cho, K , Zeng, Jian , Visscher, PM , Denny, JC , Million Veteran Program, , Lifelines Cohort Study, , CHARGE consortium, , ICBP Consortium, , Levy, D , Edwards, TL , Munroe, PB , Snieder, H , Chasman, Daniel I. , Warren, HR , Morris, Andrew P. , Caulfield, Mark J. , Hwang, Shih-Jen , Kooner, Jaspal S. , Xie, Tian , Attia, John R. , Attia, JR , Morrison, AC , Loos, RJF , Kristiansson, K , Schmidt, R , Hicks, AA , Pramstaller, PP , Nelson, CP , Samani, NJ , Vaez, Ahmad , Risch, L , Gyllensten, U , Melander, O , Riese, H , Wilson, JF , Campbell, H , Rich, SS , Psaty, BM , Lu, Y , Rotter, JI , Williams, Ariel , Guo, X , Rice, KM , Vollenweider, P , Sundström, J , Langenberg, C , Tobin, MD , Giedraitis, V , Luan, J , Tuomilehto, J , Kutalik, Z , Goleva, Slavina B. , Ripatti, S , Salomaa, V , Girotto, G , Trompet, S , Jukema, JW , van der Harst, P , Ridker, PM , Giulianini, F , Vitart, V , Goel, A , Ani, Alireza , Watkins, H , Harris, SE , Deary, IJ , van der Most, PJ , Oldehinkel, AJ , Keavney, BD , Hayward, C , Campbell, A , Boehnke, M , Scott, LJ , Evangelou, Evangelos , Boutin, T , Mamasoula, C , Järvelin, M-R , Peters, A , Gieger, C , Lakatta, EG , Cucca, F , Hui, J , Knekt, P , Enroth, S , Hellwege, Jacklyn N. , De Borst, MH , Polašek, O , Concas, MP , Catamo, E , Cocca, M , Li-Gao, R , Hofer, E , Schmidt, H , Spedicati, B , Waldenberger, M , Yengo, Loic , Strachan, DP , Laan, M , Teumer, A , Dörr, M , Gudnason, V , Cook, JP , Ruggiero, D , Kolcic, I , Boerwinkle, E , Traglia, M
- Resource Type: journal article
- Date: 2024
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting
- Creator: Chauhan, Ganesh , Adams, Hieab H. H. , Satizabal, Claudia L. , Bis, Joshua C. , Teumer, Alexander , Sargurupremraj, Muralidharan , Hofer, Edith , Trompet, Stella , Hilal, Saima , Smith, Albert Vernon , Jian, Xueqiu , Malik, Rainer , Traylor, Matthew , Pulit, Sara L. , Amouyel, Philippe , Mazoyer, Bernard , Zhu, Yi-Cheung , Kaffashian, Sara , Schilling, Sabrina , Beecham, Gary W. , Montine, Thomas J. , Schellenberg, G. D. , Kjartansson, O. , Guðnason, V. , Knopman, D. S. , Griswold, M. E. , Windham, B. G. , Gottesman, R. F. , Mosley, T. H. , Schmidt, R. , Saba, Y. , Schmidt, H. , Takeuchi, F. , Yamaguchi, S. , Nabika, T. , Kato, N , Rajan, K. B. , Aggarwal, N. T. , De Jager, P. L. , Evans, D. A. , Psaty, B M. , Rotter, J. I. , Rice, K. , Lopez, O. L. , Liao, J. , Chen, C. , Cheng, C.Y. , Wong, T. Y. , Ikram, M. K. , van der Lee, S. J. , Amin, N. , Chouraki, V. , Destefano, A. L. , Aparicio, H. J. , Romero, J. R. , Maillard, P. , Decarli, C. , Wardlaw, J. M. , Del C. Valdés Hernández, M. , Luciano, M. , Liewald, D. , Deary, I. J. , Starr, J. M. , Bastin, M. E. , Maniega, S. M. , Slagboom, P. E. , Beekman, M. , Deelen, J. , Uh, H. W. , Lemmens, R. , Brodaty, H. , Wright, MJ. , Ames, D. , Boncoraglio, G. B. , Hopewell, J. C. , Beecham, A. H. , Blanton, S. H. , Wright, C. B. , Sacco, R. L. , Wen, W. , Thalamuthu, A. , Armstrong, N. J. , Chong, E. , Schofield, P. R. , Kwok, J. B. , van der Grond, J. , Stott, D. J. , Ford, I. , Jukema, J. W. , Vernooij, M. W. , Hofman, A. , Uitterlinden, A. G. , van der Lugt, A. , Wittfeld, K. , Grabe, H. J. , Hosten, N. , von Sarnowski, B. , Völker, U. , Levi, Christopher , Jimenez-Conde, J. , Sharma, P. , Sudlow, C. L. M. , Rosand, J. , Woo, D. , Cole, J. W. , Mechia, J. F. , Slowik, A. , Thijs, V. , Lindgren, A. , Melander, O. , Grewal, R. P. , Rundek, T. , Rexrode, K. , Arnett, D. K. , Jern, C. , Johnson, J. A. , Benavente, O. R. , Asselbergs, F. R. , Srikanth, V. , Thomson, R. , McWhirter, R. , Moran, C. , Callisaya, M. , Phan, T. , Rutten-Jacobs, L. C. A. , Bevan, S. , Tzourio, C. , Mather, K. A. , Sachdev, P. S. , van Duijn, C. M. , Worrall, B. B. , Dichgans, M. , Kittner, S. J. , Markus, H. S. , Ikram, M. A. , Fornage, M. , Launer, L. J. , Seshadri, S. , Longstreth, W. T. , Debette, S.
- Resource Type: journal article
- Date: 2019
Genome-wide association meta-analysis of functional outcome after ischemic stroke
- Creator: Söderholm, Martin , Pedersen, Annie , Jood, Katarina , Lee, Jin-Moo , Lemmens, Robin , Levi, Christopher , Mitchell, Braxton D. , Norrving, Bo , Rannikmäe, Kristiina , Rost, Natalia S. , Rosand, Jonathan , Rothwell, Peter M. , Lorentzen, Erik , Scott, Rodney , Strbian, Daniel , Sturm, Jonathan W. , Sudlow, Cathie , Traylor, Matthew , Thijs, Vincent , Tatlisumak, Turgut , Woo, Daniel , Worrall, Bradford B. , Maguire, Jane M. , Stanne, Tara M. , Lindgren, Arne , Jern, Christina , Bevan, Steve , Olsson, Maja , Cole, John W. , Fernandez-Cadenas, Israel , Hankey, Graeme J. , Jimenez-Conde, Jordi
- Resource Type: journal article
- Date: 2019
Serum magnesium and calcium levels in relation to ischemic stroke: mendelian randomization study
- Creator: Larsson, Susanna C. , Traylor, Matthew , Okada, Y , Levi, Christopher R. , Mishra, A , Rutten-Jacobs, L , Giese, AK , Van Der Laan, SW , Gretarsdottir, S , Anderson, CD , Chong, M , Adams, HHH , Ago, T , Burgess, Stephen , Almgren, P , Amouyel, P , Ay, H , Bartz, RM , Benavente, OR , Bevan, S , Brown, RD , Butterworth, AS , Carrera, C , Carty, CL , Boncoraglio, Giorgio B. , Chasman, DI , Chen, WM , Cole, JW , Correa, A , Cotlarciuc, I , Cruchaga, C , Danesh, J , De Bakker, PIW , Destefano, AL , Hoed, MD , Jern, Christina , Duan, Q , Engelter, ST , Falcone, GJ , Gottesman, RF , Grewal, RP , Gudnason, V , Gustafsson, S , Haessler, J , Harris, TB , Hassan, A , Michaëlsson, Karl , Havulinna, AS , Heckbert, SR , Holliday, Elizabeth G. , Howard, G , Hsu, FC , Hyacinth, HI , Ikram, MA , Ingelsson, E , Irvin, MR , Jian, X , Markus, Hugh S. , Jiménez-Conde, J , Johnson, JA , Jukema, JW , Kanai, M , Keene, KL , Kissela, BM , Kleindorfer, DO , Kooperberg, C , Kubo, M , Lange, LA , Malik, R , Langefeld, CD , Langenberg, C , Launer, LJ , Lee, JM , Lemmens, R , Leys, D , Lewis, CM , Lin, WY , Lindgren, AG , Lorentzen, E , Chauhan, G , Magnusson, PK , Maguire, J , Manichaikul, A , McArdle, PF , Meschia, JF , Mitchell, BD , Mosley, TH , Nalls, MA , Ninomiya, T , O'Donnell, MJ , Sargurupremraj, M , Psaty, BM , Pulit, SL , Rannikmäe, K , Reiner, AP , Rexrode, KM , Rice, K , Rich, SS , Ridker, PM , Rost, NS , Rothwell, PM
- Resource Type: journal article
- Date: 2019
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
- Creator: Malik, Rainer , Chauhan, Ganesh , Anderson, Christopher D. , Chong, Michael , Adams, Hieab H. H. , Ago, Tetsuro , Almgren, Peter , Amouyel, Philippe , Ay, Hakan , Bartz, Traci M. , Benavente, Oscar R. , Bevan, Steve , Traylor, Matthew , Holliday, Elizabeth G. , Attia, John , Levi, Christopher R. , Carrera, C , Carty, CL , Chasman, DI , Chen, W-M , Cole, JW , Correa, A , Cotlarciuc, I , Sargurupremraj, Muralidharan , Cruchaga, C , Danesh, J , de Bakker, PIW , DeStefano, AL , Den Hoed, M , Duan, Q , Engelter, ST , Falcone, GJ , Gottesman, RF , Grewal, RP , Okada, Yukinori , Gudnason, V , Gustafsson, S , Haessler, J , Harris, TB , Hassan, A , Havulinna, AS , Heckbert, SR , Holliday, EG , Howard, G , Hsu, F-C , Mishra, Aniket , Hyacinth, HI , Ikram, MA , Ingelsson, E , Irvin, MR , Jian, X , Jiménez-Conde, J , Johnson, JA , Jukema, JW , Kanai, M , Keene, KL , Rutten-Jacobs, Loes , Kissela, BM , Kleindorfer, DO , Kooperberg, C , Kubo, M , Lange, LA , Langefeld, CD , Langenberg, C , Launer, LJ , Lee, J-M , Lemmens, R , Giese, Anne-Katrin , van der Laan, Sander W. , Gretarsdottir, Solveig
- Resource Type: journal article
- Date: 2018
Genetic variation at 16q24.2 is associated with small vessel stroke
- Creator: Traylor, Matthew , Malik, Rainer , Yet, Idil , Spector, Tim D. , Bell, Jordana T. , Hannon, Ellis , Mill, Jonathan , Chauhan, Ganesh , Debette, Stephanie , Bis, Joshua C. , Longstreth, W. T. , Ikram, M. Arfan , Nalls, Mike A. , Levi, Chris , Cotlarciuc, Iona , Radmanesh, Farid , Thorleifsson, Gudmar , Hanscombe, Ken B. , Langefeld, Carl , Saleheen, Danish , Rost, Natalia S.
- Resource Type: journal article
- Date: 2017
Association of MTHFR C677T genotype with ischemic stroke is confined to cerebral small vessel disease subtype
- Creator: Rutten-Jacobs, Loes C. A. , Traylor, Matthew , Levi, Christopher , Rost, Natalia S. , Rosand, Jonathan , Hassan, Ahamad , Bevan, Steve , Markus, Hugh S. , Adib-Samii, Ppneh , Thijs, Vincent , Sudlow, Cathie , Rothwell, Peter M. , Boncoraglio, Giorgio , Dichgans, Martin , Meschia, James , Maguire, Jane
- Resource Type: journal article
- Date: 2016
Genetic associations with white matter hyperintensities confer risk of lacunar stroke
- Creator: Traylor, Matthew , Rutten-Jacobs, Loes C. A. , Dichgans, Martin , Markus, Hugh S. , Thijs, Vincent , Holliday, Elizabeth G. , Levi, Chris , Bevan, Steve , Malik, Rainer , Boncoraglio, Giorgio , Sudlow, Cathie , Rothwell, Peter M.
- Resource Type: journal article
- Date: 2016
Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2
- Creator: Cheng, Yu-Ching , Stanne, Tara M. , Cole, John W. , O'Connell, Jeffrey R. , Danesh, John , Rasheed, Asif , Zhao, Wei , Engelter, Stefan , Grond-Ginsbach, Caspar , Kamatani, Yoichiro , Lathrop, Mark , Leys, Didier , Giese, Anne-Katrin , Levi, Christopher , Ho, Weang Kee , Traylor, Matthew , Amouyel, Philippe , Holliday, Elizabeth G. , Malik, Rainer , Xu, Huichun , Kittner, Steven J.
- Resource Type: journal article
- Date: 2016
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke
- Creator: Traylor, Matthew , Zhang, Cathy R. , Fitzpatrick, Kaitlin , Kanakis, Allison , Barrick, Thomas R. , Moynihan, Barry , Lewis, Cathryn M. , Boncoraglio, Giorgio B. , Lemmens, Robin , Thijs, Vincent , Sudlow, Cathie , Wardlaw, Joanna , Adib-Samii, Poneh , Levi, Christopher , Bevan, Steve , Devan, William J. , Parsons, Owen E. , Lanfranconi, Silvia , Gregory, Sarah , Cloonan, Lisa , Falcone, Guido J. , Radmanesh, Fadrid
- Resource Type: journal article
- Date: 2016
Low-frequency and common genetic variation in ischemic stroke: the METASTROKE collaboration
- Creator: Malik, Rainer , Traylor, Matthew , Battey, Thomas W. K. , Berger, Klaus , Boncoraglio, Giorgio B. , Chauhan, Ganesh , Cheng, Yu-Ching , Chen, Wei-Min , Clarke, Robert , Cotlarciuc, Ioana , Debette, Stephanie , Falcone, Guido J. , Pulit, Sara L. , Levi, Christopher R. , Bevan, Steve , Hopewell, Jemma C. , Holliday, Elizabeth G. , Zhao, Wei , Abrantes, Patricia , Amouyel, Philippe , Attia, John R.
- Resource Type: journal article
- Date: 2016
Common NOTCH3 variants and cerebral small-vessel disease
- Creator: Rutten-Jacobs, Loes C. A. , Traylor, Matthew , Levi, Christopher , Rost, Natalia S. , Rosand, Jonathan , Hassan, Ahamad , Markus, Hugh S. , Adib-Samii, Poneh , Thijs, Vincent , Sudlow, Cathie , Rothwell, Peter M. , Boncoraglio, Giorgio , Dichgans, Martin , Bevan, Steve , Meschia, James
- Resource Type: journal article
- Date: 2015
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
- Creator: Rannikmäe, Kristiina , Davies, Gail , Deka, Ranjan , Woo, Jessica G. , Martin, Lisa J. , Jimenez-Conde, Jordi , Selim, Magdy , Brown, Devin L. , Silliman, Scott L. , Kidwell, Chelsea S. , Montaner, Joan , Langefeld, Carl D. , Thomson, Pippa A. , Holliday, Elizabeth G. , Levi, Christopher R. , Attia, John , Rothwell, Peter M. , Poole, Deborah L. , Bevan, Steve , Devan, William J. , Falcone, Guido J. , Traylor, Matthew , Anderson, Christopher D. , Battey, Thomas W. K. , Radmanesh, Farid
- Resource Type: journal article
- Date: 2015
Differences in common genetic predisposition to ischemic stroke by age and sex
- Creator: Traylor, Matthew , Rutten-Jacobs, Loes C. A. , Dichgans, Martin , Levi, Chris , Lewis, Cathryn M. , Markus, Hugh S. , Holliday, Elizabeth G. , Malik, Rainer , Sudlow, Cathie , Rothwell, Peter M. , Maguire, Jane M. , Koblar, Simon A. , Bevan, Steve , Boncoraglio, Giorgio
- Resource Type: journal article
- Date: 2015
Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke
- Creator: Adib-Samii, Poneh , Devan, William , Rothwell, Peter M. , Sudlow, Cathie , Boncoraglio, Giorgio B. , Meschia, James F. , Levi, Chris , Dichgans, Martin , Bevan, Steve , Rosand, Jonathan , Rost, Natalia S. , Markus, Hugh S. , Traylor, Matthew , Lanfranconi, Silvia , Zhang, Cathy R. , Cloonan, Lisa , Falcone, Guido J. , Radmanesh, Farid , Fitzpatrick, Kaitlin , Kanakis, Allison
- Resource Type: journal article
- Date: 2015
Genetic overlap between diagnostic subtypes of ischemic stroke
- Creator: Holliday, Elizabeth G. , Traylor, Matthew , Boncoraglio, Giorgio B. , Clarke, Robert , Cole, John W. , Fornage, Myriam , Furie, Karen L. , Ikram, M. Arfan , Jannes, Jim , Kittner, Steven J. , Lincz, Lisa F. , Maguire, Jane M. , Malik, Rainer , Oldmeadow, Christopher , Scott, Rodney J. , Levi, Christopher , Attia, John , Bevan, Steve , Falcone, Guido , Hopewell, Jemma C. , Cheng, Yu-Ching , Cotlarciuc, Ioana , Bis, Joshua C. , Boerwinkle, Eric
- Resource Type: journal article
- Date: 2015
No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study
- Creator: Achterberg, Sefanja , Kappelle, L. Jaap , Mali, W.P.T.M. , Doevendans, P.A. , Farrall, Martin , Holliday, Elizabeth G. , Sudlow, Cathie , Hopewell, Jemma C. , Cheng, Yu-Ching , Fornage, Myriam , Ikram, M. Arfan , Malik, Rainer , De Bakker, Paul I. W. , Bevan, Steve , Thorsteinsdottir, Unnur , DeStefano, Anita L. , Worrall, Bradford B. , Reiner, Alex P. , Mitchell, Braxtin D. , Clarke, Robert , Levi, Christopher , Seshadri, Sudha , Boncoraglio, Giorgio B. , Traylor, Matthew , Sharma, Pankaj , Bis, Joshua C. , Gretarsdottir, Solveig , Psaty, Bruce M. , Rothwell, Peter M. , Rosand, Jonathan , Meschia, James F. , Stefansson, Kari , Dichgans, Martin , Markus, Hugh S. , Algra, Ale , Van Der Graaf, Y. , Grobbee, D.E. , Rutten, G.E.H.M. , Visseren, F.L.J. , Moll, F.L.
- Resource Type: journal article
- Date: 2015
Shared genetic basis for migraine and ischemic stroke: a genome-wide analysis of common variants
- Creator: Malik, Rainer , Freilinger, Tobias , Bis, Joshua C. , Hopewell, Jemma C. , Ferrari, Michel D. , Rannikmae, Kristiina , Wessman, Maija , Kallela, Mikko , Kubisch, Christian , Fornage, Myriam , Meschia, James F. , Lehtimäki, Terho , Winsvold, Bendik S. , Sudlow, Cathie , Clarke, Robert , Chasman, Daniel I. , Mitchell, Braxton D. , Maguire, Jane , Kaprio, Jakko , Farrall, Martin , Raitakari, Olli T. , Kurth, Tobias , Ikram, M. Arfan , Anttila, Verneri , Reiner, Alex P. , Longstreth, W. T. , Rothwell, Peter M. , Strachan, David P. , Sharma, Pankaj , Seshadri, Sudha , Quaye, Lydia , Cherkas, Lynn , Schürks, Markus , Rosand, Jonathan , Vander Heiden, Jason , Ligthart, Lannie , Boncoraglio, Giorgio B. , Davey Smith, George , van Duijn, Cornelia M. , Stefansson, Kari , Worrall, Bradford B. , Nyholt, Dale R. , Markus, Hugh S. , van den Maagdenberg, Arn M. J. M. , Cotsapas, Chris , Traylor, Matthew , Zwart, John A. , Palotie, Aarno , Dichgans, Martin , de Vries, Boukje , Holliday, Elizabeth G. , Terwindt, Gisela M. , Sturm, Jonathan
- Resource Type: journal article
- Date: 2015
A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach
- Creator: Traylor, Matthew , Mäkelä, Kari-Matti , Malik, Rainer , Sudlow, Cathie , Bevan, Steve , Raitoharju, Emma , Oksala, Niku , Thijs, Vincent , Lemmens, Robin , Lindgren, Arne , Slowik, Agnieszka , Kilarski, Laura L. , Maguire, Jane M. , Walters, Matthew , Algra, Ale , Sharma, Pankaj , Attia, John R. , Boncoraglio, Giorgio B. , Rothwell, Peter M. , de Bakker, Paul I. W. , Bis, Joshua C. , Saleheen, Danish , Holliday, ELizabeth G. , Kittner, Steven J. , Mitchell, Braxton D. , Rosand, Jonathan , Meschia, James F. , Levi, Christopher , Dichgans, Martin , Lehtimäki, Terho , Lewis, Cathryn M. , Markus, Hugh S. , Devan, William J. , Nalls, Mike A. , Wiggins, Kerri L. , Zhao, Wei , Cheng, Yu-Ching , Achterberg, Sefanja
- Resource Type: journal article
- Date: 2014
Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12
- Creator: Kilarski, Laura L. , Achterberg, Sefanja , Walters, Matthew , Worrall, Bradford B. , Sale, Michele M. , Algra, Ale , Kappelle, L. Jaap , Wijmenga, Cisca , Norrving, Bo , Sandling, Johanna K. , Röennblom, Lars , Goris, An , Devan, William J. , Franke, Andre , Sudlow, Cathie , Rothwell, Peter M. , Levi, Christopher , Holliday, Elizabeth G. , Fornage, Myriam , Psaty, Bruce , Gretarsdottir, Solveig , Thorsteinsdottir, Unnar , Seshadri, Sudha , Traylor, Matthew , Mitchell, Braxton D. , Kittner, Steven , Clarke, Robert , Hopewell, Jemma C. , Bis, Joshua C. , Boncoraglio, Giorgio B. , Meschia, James , Ikram, M. Arfan , Hansen, Bjorn M. , Montaner, Joan , Malik, Rainer , Thorleifsson, Gudmar , Stefanson, Kari , Rosand, Jonathan , de Bakker, Paul I. W. , Farrall, Martin , Dichgans, Martin , Markus, Hugh S. , Bevan, Steve , Lindgren, Arne , Pare, Guillame , Sharma, Pankaj , Slowik, Agniescka , Thijs, Vincent
- Resource Type: journal article
- Date: 2014