PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
- Creator: Duchatel, Ryan J. , Jackson, Evangeline R. , Kearney, Padraic S. , Jamaluddin, M. Fairuz B. , Douglas, Alicia M. , Beitaki, Tyrone , McEwen, Holly P. , Persson, Mika L. , Hocke, Emily A. , Jain, Vaibhav , Aksu, Michael , Manning, Elizabeth E. , Parackal, Sarah G. , Murray, Heather C. , Verrills, Nicole M. , Hua, Susan , Cairns, Murray J. , Alvaro, Frank , Dayas, Christopher V. , Dun, Matthew D. , Hua, S , de Bock, CE , Colino-Sanguino, Y , Kiltschewskij, Dylan , Valdes-Mora, F , Tsoli, M , Ziegler, DS , Cairns, MJ , Raabe, EH , Vitanza, NA , Hulleman, E , Phoenix, TN , Koschmann, C , Alvaro, F , Findlay, Izac J. , Dayas, CV , Tinkle, CL , Wheeler, H , Whittle, JR , Eisenstat, DD , Firestein, R , Mueller, S , Valvi, S , Hansford, JR , Ashley, DM , Mannan, Abdul , Gregory, SG , Kilburn, LB , Nazarian, J , Cain, JE , Dun, MD , Staudt, Dilana E. , Thomas, Bryce C. , Germon, Zacary P. , Laternser, Sandra
- Resource Type: journal article
- Date: 2024
The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models
- Creator: de la Nava, Daniel , Ausejo-Mauleon, Iker , Tallon-Cobos, Antonio Carlos , Hernandez-Osuna, Reyes , Marco-Sanz, Javier , Dhandapani, Laasya , Hervás-Corpión, Irati , Becher, Oren J. , Nazarian, Javad , Mueller, Sabine , Phoenix, Timothy N. , van der Lugt, Jasper , Laspidea, Virginia , Hernaez, Mikel , Guruceaga, E , Koschmann, C , Venneti, S , Allen, JE , Dun, Matthew D. , Fueyo, J , Gomez-Manzano, C , Perez-Larraya, JG , Patiño-García, A , Gonzalez-Huarriz, Marisol , Labiano, S , Alonso, MM , Lacalle, Andrea , Casares, Noelia , Zalacain, Marta , Marrodan, Lucía , García-Moure, Marc , Ochoa, Maria C.
- Resource Type: journal article
- Date: 2024
Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
- Creator: Venneti, Sriram , Kawakibi, Abed Rahman , Ramage, Samuel , Chi, Andrew , Wen, Patrick Y. , Arrillaga-Romany, Isabel , Batchelor, Tracy T. , Butowski, Nicholas A. , Sumrall, Ashley , Shonka, Nicole , Harrison, Rebecca A. , de Groot, John , Ji, Sunjong , Mehta, M , Hall, MD , Daghistani, D , Cloughesy, TF , Ellingson, BM , Beccaria, K , Varlet, P , Kim, MM , Umemura, Y , Garton, H , Waszak, Sebastian M. , Franson, A , Schwartz, J , Jain, R , Kachman, M , Baum, H , Burant, CF , Mottl, SL , Cartaxo, RT , John, V , Messinger, D , Sweha, StefanR , Qin, T , Peterson, E , Sajjakulnukit, P , Ravi, K , Waugh, A , Walling, D , Ding, Y , Xia, Z , Schwendeman, A , Hawes, D , Mota, Mateus , Yang, F , Judkins, AR , Wahl, D , Lyssiotis, CA , de la Nava, D , Alonso, MM , Eze, A , Spitzer, J , Schmidt, SV , Duchatel, Ryan J. , Pun, Matthew , Dun, Matthew D. , Cain, JE , Jiang, L , Stopka, SA , Baquer, G , Regan, MS , Filbin, MG , Agar, NYR , Zhao, L , Kumar-Sinha, C , Deogharkar, Akash , Mody, R , Chinnaiyan, A , Kurokawa, R , Pratt, D , Yadav, VN , Grill, J , Kline, C , Mueller, S , Resnick, A , Nazarian, J , Chung, Chan , Allen, JE , Odia, Y , Gardner, SL , Koschmann, C , Tarapore, Rohinton S.
- Resource Type: journal article
- Date: 2023
ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
- Creator: Jackson, Evangeline R. , Duchatel, Ryan J. , Le Grand, Marion , Kearney, Padraic S. , Douglas, Alicia M. , Findlay, Izac J. , Germon, Zacary P. , McEwen, Holly P. , Beitaki, Tyrone S. , Patabendige, Adjanie , Skerrett-Byrne, David A. , Nixon, Brett , Staudt, Dilana E. , Smith, Nathan D. , Day, B , Manoharan, N , Nagabushan, S , Hansford, JR , Govender, D , McCowage, GB , Firestein, R , Howlett, M , Endersby, R , Persson, Mika L. , Gottardo, NG , Alvaro, F , Waszak, SM , Larsen, MR , Colino-Sanguino, Y , Valdés-Mora, F , Rakotomalala, A , Meignan, S , Pasquier, E , Andre, N , Mannan, Abdul , Hulleman, E , Eisenstat, DD , Vitanza, NA , Nazarian, J , Koschmann, C , Mueller, S , Cain, JE , Dun, MD , Yadavilli, Sridevi , Parackal, Sarah , Game, Shaye , Chong, Wai Chin , Jayasekara, W. Samantha N.
- Resource Type: journal article
- Date: 2023
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
- Creator: Messinger, Dana , Harris, Micah K. , Qin, Tingting , Mullan, Brendan , Siada, Ruby , Ravindran, Ramya , Niculcea, Michael , Dowling, Abigail R. , Bradin, Joshua , Ginn, Kevin F. , Gener, Melissa A. H. , Dorris, Kathleen , Cummings, Jessica R. , Vitanza, Nicholas A. , Schmidt, SV , Spitzer, J , Li, J , Filbin, MG , Cao, X , Castro, MG , Lowenstein, PR , Mody, R , Chinnaiyan, A , Thomas, Chase , Desprez, PY , McAllister, S , Dun, Matthew D. , Hawkins, C , Waszak, SM , Venneti, S , Koschmann, C , Yadav, VN , Yang, Tao , Sweha, Stefan R. , Woo, Rinette , Siddaway, Robert , Burkert, Martin , Stallard, Stefanie
- Resource Type: journal article
- Date: 2023
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
- Creator: Przystal, Justyna M. , Cosentino, Chiara Cianciolo , Biery, Matt C. , Myers, Carrie , Olson, James M. , Panditharatna, Eshini , Kritzer, Bettina , Mourabit, Sulayaman , Vitanza, Nicholas A. , Filbin, Mariella G. , de Iuliis, Geoffry N. , Dun, Matthew D. , Yadavilli, Sridevi , Koschmann, C , Cain, JE , Grotzer, MA , Waszak, SM , Mueller, S , Nazarian, J , Zhang, Jie , Laternser, Sandra , Bonner, Erin R. , Prasad, Rachna , Dawood, Adam A. , Lobeto, Nina , Chong, Wai Chin
- Resource Type: journal article
- Date: 2022
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
- Creator: Liu, Ilon , Jiang, Li , Mire, Hafsa M. , Madlener, Sibylle , Mayr, Lisa , Quezada, Michael A. , Trissal, Maria , Panditharatna, Eshini , Ernst, Kati J. , Vogelzang, Jayne , Gatesman, Taylor A. , Halbert, Matthew E. , Samuelsson, Erik R. , Palova, Hana , Pokorna, P , Sterba, J , Slaby, O , Geyeregger, R , Diaz, A , Findlay, Izac J. , Dun, Matthew D. , Resnick, A , Suvà, ML , Marco Salas, Sergio , Jones, DTW , Agnihotri, S , Svedlund, J , Koschmann, C , Haberler, C , Czech, T , Slavc, I , Cotter, JA , Ligon, KL , Alexandrescu, S , Beck, Alexander , Yung, WKA , Arrillaga-Romany, I , Gojo, J , Monje, M , Nilsson, M , Filbin, MG , Hack, Olivia A. , Jeong, Daeun , Shaw, McKenzie L. , Englinger, Bernhard , LaBelle, Jenna
- Resource Type: journal article
- Date: 2022