A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered
- Creator: Jackson, Evangeline R. , Persson, Mika L. , Fish, Cameron J. , Findlay, Izac J. , Mueller, Sabine , Nazarian, Javad , Hulleman, Esther , van der Lugt, Jasper , Duchatel, Ryan J. , Dun, Matthew D.
- Resource Type: journal article
- Date: 2024
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
- Creator: Duchatel, Ryan J. , Jackson, Evangeline R. , Kearney, Padraic S. , Jamaluddin, M. Fairuz B. , Douglas, Alicia M. , Beitaki, Tyrone , McEwen, Holly P. , Persson, Mika L. , Hocke, Emily A. , Jain, Vaibhav , Aksu, Michael , Manning, Elizabeth E. , Parackal, Sarah G. , Murray, Heather C. , Verrills, Nicole M. , Hua, Susan , Cairns, Murray J. , Alvaro, Frank , Dayas, Christopher V. , Dun, Matthew D. , Hua, S , de Bock, CE , Colino-Sanguino, Y , Kiltschewskij, Dylan , Valdes-Mora, F , Tsoli, M , Ziegler, DS , Cairns, MJ , Raabe, EH , Vitanza, NA , Hulleman, E , Phoenix, TN , Koschmann, C , Alvaro, F , Findlay, Izac J. , Dayas, CV , Tinkle, CL , Wheeler, H , Whittle, JR , Eisenstat, DD , Firestein, R , Mueller, S , Valvi, S , Hansford, JR , Ashley, DM , Mannan, Abdul , Gregory, SG , Kilburn, LB , Nazarian, J , Cain, JE , Dun, MD , Staudt, Dilana E. , Thomas, Bryce C. , Germon, Zacary P. , Laternser, Sandra
- Resource Type: journal article
- Date: 2024
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies
- Creator: Germon, Zacary P. , Sillar, Jonathan R. , McLachlan, Tabitha , Schjenken, John E. , Skerrett-Byrne, David A. , Huang, Honggang , Melo-Braga, Marcella N. , Plank, Maximillan W. , Alvaro, Frank , Chamberlain, Janis , De Iuliis, Geoff , Aitken, R. John , Mannan, Abdul , Nixon, Brett , Wei, AH , Enjeti, Anoop K. , Huang, Y , Lock, RB , Larsen, MR , Lee, Heather , Vaghjiani, V , Cain, JE , de Bock, CE , Duchatel, Ryan J. , Verrills, Nicole M. , Dun, Matthew D. , Staudt, Dilana , Murray, Heather C. , Findlay, Izac J. , Jackson, Evangeline R. , McEwen, Holly P. , Douglas, Alicia M.
- Resource Type: journal article
- Date: 2023
ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
- Creator: Jackson, Evangeline R. , Duchatel, Ryan J. , Le Grand, Marion , Kearney, Padraic S. , Douglas, Alicia M. , Findlay, Izac J. , Germon, Zacary P. , McEwen, Holly P. , Beitaki, Tyrone S. , Patabendige, Adjanie , Skerrett-Byrne, David A. , Nixon, Brett , Staudt, Dilana E. , Smith, Nathan D. , Day, B , Manoharan, N , Nagabushan, S , Hansford, JR , Govender, D , McCowage, GB , Firestein, R , Howlett, M , Endersby, R , Persson, Mika L. , Gottardo, NG , Alvaro, F , Waszak, SM , Larsen, MR , Colino-Sanguino, Y , Valdés-Mora, F , Rakotomalala, A , Meignan, S , Pasquier, E , Andre, N , Mannan, Abdul , Hulleman, E , Eisenstat, DD , Vitanza, NA , Nazarian, J , Koschmann, C , Mueller, S , Cain, JE , Dun, MD , Yadavilli, Sridevi , Parackal, Sarah , Game, Shaye , Chong, Wai Chin , Jayasekara, W. Samantha N.
- Resource Type: journal article
- Date: 2023
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers
- Creator: McLachlan, Tabitha , Matthews, William C. , Dun, Matthew D. , Jackson, Evangeline R. , Staudt, Dilana E. , Douglas, Alicia M. , Findlay, Izac J. , Persson, Mika L. , Duchatel, Ryan J. , Mannan, Abdul , Germon, Zacary P.
- Resource Type: journal article
- Date: 2022
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
- Creator: Findlay, Izac J. , De Iuliis, Geoffry N. , Duchatel, Ryan J. , Jackson, Evangeline R. , Vitanza, Nicholas A. , Cain, Jason E. , Waszak, Sebastian M. , Dun, Matthew D.
- Resource Type: journal article
- Date: 2022
Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection
- Creator: Staudt, Dilana E. , Murray, Heather C. , Findlay, Izac J. , Kearney, Padraic S. , Mannan, Abdul , McEwen, Holly P. , Douglas, Alicia M. , Nixon, Brett , Verrills, Nicole M. , Dun, Matthew D. , Skerrett-Byrne, David A. , Smith, Nathan D. , Jamaluddin, M. Fairuz B. , Kahl, Richard G. S. , Duchatel, Ryan J. , Germon, Zacary P. , McLachlan, Tabitha , Jackson, Evangeline R.
- Resource Type: journal article
- Date: 2022
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
- Creator: Liu, Ilon , Jiang, Li , Mire, Hafsa M. , Madlener, Sibylle , Mayr, Lisa , Quezada, Michael A. , Trissal, Maria , Panditharatna, Eshini , Ernst, Kati J. , Vogelzang, Jayne , Gatesman, Taylor A. , Halbert, Matthew E. , Samuelsson, Erik R. , Palova, Hana , Pokorna, P , Sterba, J , Slaby, O , Geyeregger, R , Diaz, A , Findlay, Izac J. , Dun, Matthew D. , Resnick, A , Suvà, ML , Marco Salas, Sergio , Jones, DTW , Agnihotri, S , Svedlund, J , Koschmann, C , Haberler, C , Czech, T , Slavc, I , Cotter, JA , Ligon, KL , Alexandrescu, S , Beck, Alexander , Yung, WKA , Arrillaga-Romany, I , Gojo, J , Monje, M , Nilsson, M , Filbin, MG , Hack, Olivia A. , Jeong, Daeun , Shaw, McKenzie L. , Englinger, Bernhard , LaBelle, Jenna
- Resource Type: journal article
- Date: 2022
Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma
- Creator: Duchatel, Ryan J. , Mannan, Abdul , Kearney, Padraic S. , Smith, Nathan D. , Hindley, Kate E. , Cain, Jason E. , André, Nicolas , La Madrid, Andres Morales , Nixon, Brett , De Iuliis, Geoffry N. , Nazarian, Javad , Irish, Kathleen , Woldu, Ameha S. , Alvaro, Frank , Eisenstat, DD , Beck, A , Vitanza, NA , Mueller, S , Morris, JC , Dun, Matthew D. , Hawtrey, Tom , Hindley, Phoebe A. , Douglas, Alicia M. , Jackson, Evangeline R. , Findlay, Izac J. , Germon, Zacary P. , Staudt, Dilana
- Resource Type: journal article
- Date: 2021