- Title
- A global core outcome measurement set for snakebite clinical trials
- Creator
- Abouyannis, Michael; Esmail, Hanif; Alcoba, Gabriel; Cammack, Nick; Chippaux, Jean-Philippe; Coldiron, Matthew E.; Gutiérrez, José; Habib, Abdulrazaq G.; Harrison, Robert A.; Isbister, Geoffrey K.; Lavonas, Eric J.; Martins, Diogo; Hamaluba, Mainga; Ribeiro, Isabela; Watson, JA; Williams, D; Casewell, NR; Walker, SA; Lalloo, DG; Ngama, Mwanajuma; Mwangudzah, Hope; Mumba, Noni; Yeri, Betty K.; Mwalukore, Salim; Alphan, Hassan J.; Aggarwal, Dinesh
- Relation
- Medecine Tropicale Et Sante Internationale Vol. 3, Issue 3, no. 421
- Publisher Link
- http://dx.doi.org/10.48327/mtsi.v3i3.2023.421
- Publisher
- Societe Francophone de Medecine Tropicale et Sante Internationale
- Resource Type
- journal article
- Date
- 2023
- Description
- Background: Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. Method: A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Results: Five universal core outcome measures should be included in all future snakebite clinical trials: mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. Conclusion: This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.
- Subject
- snakebite; envenoming; clincial trials; standardisation; outcome measurement; endpoint criterium
- Identifier
- http://hdl.handle.net/1959.13/1494706
- Identifier
- uon:53857
- Identifier
- ISSN:2778-2034
- Language
- french
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