A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids

Title: A facile, protic ionic liquid route to N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides and N-substituted 3-oxoisoindoline-4-carboxylic acids
Creator: Gordon, Christopher P.; Byrne, Nolene; McCluskey, Adam
Relation: Green Chemistry Vol. 12, Issue 6, p. 1000-1006
Publisher Link: http://dx.doi.org/10.1039/b924835h
Publisher: Royal Society of Chemistry
Resource Type: journal article
Date: 2010
Description: Treatment of highly decorated bicyclo[2.2.1]heptadienes with the protic ionic liquid, TfOH:TEA effected quantitative conversion to the corresponding N-substituted 5-hydroxy-4-methyl-3-oxoisoindoline-1-carboxamides. This approach provides rapid access important chemical space for the rapid development of highly functionalised oxoisoindoline and is highly substrate tolerant.
Subject: anticancer; norcantharidin analogs; protein phosphate 2A; radical cyclization; lennoxzmine
Identifier: http://hdl.handle.net/1959.13/923193
Identifier: uon:9676
Identifier: ISSN:1463-9262
Language: eng
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