Impact of estrogenic compounds on DNA integrity in human spermatozoa: evidence for cross-linking and redox cycling activities (editorial)

Title: Impact of estrogenic compounds on DNA integrity in human spermatozoa: evidence for cross-linking and redox cycling activities (editorial)
Creator: Bennetts, L. E.; De Iuliis, G. N.; Nixon, B.; Kime, M.; Zelski, K.; McVicar, C. M.; Lewis, S. E.; Aitken, R. J.
Relation: Journal of Urology Vol. 181, Issue 2, p. 914-915
Publisher Link: http://dx.doi.org/10.1016/j.juro.2008.10.084
Publisher: Lippincott, Williams & Wilkins
Resource Type: journal article
Date: 2009
Description: A great deal of circumstantial evidence has linked DNA damage in human spermatozoa with adverse reproductive outcomes including reduced fertility and high rates of miscarriage. Although oxidative stress is thought to make a significant contribution to DNA damage in the male germ line, the factors responsible for creating this stress have not been elucidated One group of compounds that are thought to be active in this context are the estrogens, either generated as a result of the endogenous metabolism of androgens within the male reproductive tract or gaining access to the latter as a consequence of environmental exposure.
Subject: impact of estrogenic compounds; DNA damage; spermatazoa; reduced fertlity; redox cycling
Identifier: uon:7952
Identifier: http://hdl.handle.net/1959.13/916302
Identifier: ISSN:0022-5347

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