- Title
- Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners
- Creator
- Cox, Amanda J.; Pyne, David B.; Gleeson, Maree; Callister, Robin
- Relation
- European Journal of Applied Physiology Vol. 107, Issue 5, p. 611-614
- Publisher Link
- http://dx.doi.org/10.1007/s00421-009-1160-0
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2009
- Description
- Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (≤2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (≥4 episodes per year; n = 8) and completed three treadmill running protocols. CRP concentrations were determined prior to and 24 h following each exercise protocol and responses compared between the two groups. Plasma concentrations of Interleukin (IL)-6, IL-8, IL-10 and the IL-1 receptor antagonist (IL-1ra) were also determined immediately, 1 h, 10 h and 24 h post-exercise. The CRP response at 24 h post-exercise was not substantially different between healthy and illness-prone athletes (~2–10%). There were small to moderate correlations between resting CRP concentrations and the peak IL-6 (r = 0.28, P = 0.04), IL-8 (r = 0.31, P = 0.03), IL-10 (r = 0.28, P = 0.05) and IL-1ra (r = 0.30, P = 0.03) concentrations post-exercise. The CRP response to exercise was not useful in distinguishing between healthy and illness-prone athletes. The relationship between resting CRP concentrations and the peak pro- and anti-inflammatory responses to exercise supports the likely involvement of CRP in the complex network regulating exercise-induced inflammatory disturbance.
- Subject
- inflammation; athletes; exercise; cytokines
- Identifier
- http://hdl.handle.net/1959.13/807213
- Identifier
- uon:7339
- Identifier
- ISSN:1439-6319
- Language
- eng
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