- Title
- APCcdh¹ activity in mouse oocytes prevents entry into the first meiotic division
- Creator
- Reis, Alexandra; Chang, Heng-Yu; Levasseur, Mark; Jones, Keith T.
- Relation
- Nature Cell Biology Vol. 8, Issue 5, p. 539-540
- Publisher Link
- http://dx.doi.org/10.1038/ncb1406
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2006
- Description
- Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh¹ is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh¹ is active in mouse oocytes and is necessary to maintain prophase arrest.
- Subject
- APCcdh¹; mouse; mammalian; cyclin; meiotic; oocytes
- Identifier
- uon:6563
- Identifier
- http://hdl.handle.net/1959.13/804244
- Identifier
- ISSN:1465-7392
- Language
- eng
- Reviewed
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