- Title
- The effects of obesity and fatty acids on medication use and bronchodilator response in asthma
- Creator
- Thompson, Cherry Anne
- Relation
- University of Newcastle Research Higher Degree Thesis
- Resource Type
- thesis
- Date
- 2021
- Description
- Research Doctorate - Doctor of Philosophy (PhD)
- Description
- The surge in global obesity prevalence, tripling since 1975 [1], poses a far-reaching public health challenge. In 2016, more than 650 million adults were obese (13% of the world’s population) [1]. Over a similar timeframe corresponding to the surge in obesity, we have seen a parallel rise in global asthma prevalence, affecting approximately 339 million people worldwide [2]. The concurrent rise in both conditions, especially in high-income countries [3], has sparked widespread interest in the obesity–asthma hypothesis. The negative consequences of obesity on clinical manifestations of asthma are far-reaching and detrimental [4, 5], including implications on asthma medication responsiveness [6, 7], presenting a significant complication in the treatment and management of disease in obese asthma patients. Indeed, obese asthma carries an even larger health and economic burden than asthma in healthy weight subjects [7]. Asthma medication guidelines do not differ for healthy weight and obese patients [8], though obese patients with asthma may not respond as well to standard medications [8]. The potential reduced efficacy of asthma medications in obesity is a major clinical problem considering its paramount role in controlling disease, reducing severity, treating life-threatening exacerbations, and preventing exercise induced bronchoconstriction.
- Subject
- obesity; asthma; medication; fatty acids; bronchodilator response
- Identifier
- http://hdl.handle.net/1959.13/1514122
- Identifier
- uon:56814
- Rights
- Copyright 2021 Cherry Anne Thompson
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Thesis | 4 MB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | ATTACHMENT02 | Abstract | 514 KB | Adobe Acrobat PDF | View Details Download |