- Title
- The Efficacy of Exercise Training for Cutaneous Microvascular Reactivity in the Foot in People with Diabetes and Obesity: Secondary Analyses from a Randomized Controlled Trial
- Creator
- Lanting, Sean; Way, Kimberley; Chuter, Vivienne; Sabag, Angelo; Sultana, Rachelle; Gerofi, James; Johnson, Nathan; Baker, Michael; Keating, Shelley; Caterson, Ian; Twigg, Stephen
- Relation
- Journal of Clinical Medicine Vol. 11, Issue 17, no. 5018
- Publisher Link
- http://dx.doi.org/10.3390/jcm11175018
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2022
- Description
- It is unclear if cutaneous microvascular dysfunction associated with diabetes and obesity can be ameliorated with exercise. We investigated the effect of 12-weeks of exercise training on cutaneous microvascular reactivity in the foot. Thirty-three inactive adults with type 2 diabetes and obesity (55% male, 56.1 ± 7.9 years, BMI: 35.8 ± 5, diabetes duration: 7.9 ± 6.3 years) were randomly allocated to 12-weeks of either (i) moderate-intensity continuous training [50–60% peak oxygen consumption (VO2peak), 30–45 min, 3 d/week], (ii) low-volume high-intensity interval training (90% VO2peak, 1–4 min, 3 d/week) or (iii) sham exercise placebo. Post-occlusive reactive hyperaemia at the hallux was determined by laser-Doppler fluxmetry. Though time to peak flux post-occlusion almost halved following moderate intensity exercise, no outcome measure reached statistical significance (p > 0.05). These secondary findings from a randomised controlled trial are the first data reporting the effect of exercise interventions on cutaneous microvascular reactivity in the foot in people with diabetes. A period of 12 weeks of moderate-intensity or low-volume high-intensity exercise may not be enough to elicit functional improvements in foot microvascular reactivity in adults with type 2 diabetes and obesity. Larger, sufficiently powered, prospective studies are necessary to determine if additional weight loss and/or higher exercise volume is required.
- Subject
- cutaneous blood flow; exercise training; laser-Doppler; microvascular reactivity; perhipheral artery disease; post-occlusive reactive hyperaemia; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1496802
- Identifier
- uon:54235
- Identifier
- ISSN:2077-0383
- Rights
- x
- Language
- eng
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