- Title
- Lactate dehydrogenase contribution to symptom persistence in long COVID: A pooled analysis
- Creator
- Udeh, Raphael; Utrero-Rico, Alberto; Dolja-Gore, Xenia; Rahmati, Masoud; McEVoy, Mark; Kenna, Tony
- Relation
- Reviews in Medical Virology Vol. 33, Issue 6, no. e2477
- Publisher Link
- http://dx.doi.org/10.1002/rmv.2477
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2023
- Description
- There's critical need for risk predictors in long COVID. This meta-analysis evaluates the evidence for an association between plasma lactate dehydrogenase (LDH) and long COVID and explores the contribution of LDH to symptoms persistent across the distinct post-acute sequelae of COVID-19 (PASC) domains. PubMed, EMBASE, Web of Science, and Google Scholar were searched for articles published up to 20 March 2023 for studies that reported data on LDH levels in COVID-19 survivors with and without PASC. Random-effect meta-analysis was employed to estimate the standardized mean difference (SMD) with corresponding 95% confidence interval of each outcome. There were a total of 8289 study participants (3338 PASC vs. 4951 controls) from 46 studies. Our meta-analysis compared to the controls showed a significant association between LDH elevation and Resp-PASC [SMD = 1.07, 95%CI = 0.72, 1.41, p = 0.01] but not Cardio-PASC [SMD = 1.79, 95%CI = −0.02, 3.61, p = 0.05], Neuro-PASC [SMD = 0.19, 95%CI = −0.24, 0.61, p = 0.40], and Gastrointestinal-PASC [SMD = 0.45, 95%CI = −1.08, 1.98, p = 0.56]. This meta-analysis suggests elevated LDH can be used for predicting Resp-PASC, but not Cardio-PASC, Neuro-PASC or gastrointestinal-PASC. Thus, elevated plasma LDH following COVID infection may be considered as a disease biomarker.
- Subject
- lactate dehydrogenase; long COVID; PASC; pooled analysis; post-COVID-19 condition
- Identifier
- http://hdl.handle.net/1959.13/1496560
- Identifier
- uon:54176
- Identifier
- ISSN:1052-9276
- Language
- eng
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