- Title
- Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters
- Creator
- Khanuja, Harpreet K.; Awasthi, Rajendra; Mehta, Meenu; Satija, Saurabh; Aljabali, Alaa A. A.; Tambuwala, Murtaza M.; Chellappan, Dinesh K.; Dua, Kamal; Dureja, Harish
- Relation
- Recent Patents on Nanotechnology Vol. 15, Issue 4, p. 351-366
- Publisher Link
- http://dx.doi.org/10.2174/1872210514666201224103010
- Publisher
- Bentham Science Publishers
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption. Methods: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar. Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention. Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.
- Subject
- nanosuspension; colloidal; stability; spin coating; high-pressure homogenization; dissolution rate
- Identifier
- http://hdl.handle.net/1959.13/1494066
- Identifier
- uon:53696
- Identifier
- ISSN:1872-2105
- Language
- eng
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