- Title
- Novel methodology to quantify dehydration in head and neck cancer radiotherapy using DIXON MRI
- Creator
- Duncan, Sophie; Walker, Amy; Kumar, Shivani; Dundas, Kylie; Bell, Katherine; Wallis, Andrew; Surjan, Yolanda; Aly, Farhannah; Lee, Mark
- Relation
- Journal of Medical Radiation Sciences Vol. 69, Issue 4, p. 448-455
- Publisher Link
- http://dx.doi.org/10.1002/jmrs.605
- Publisher
- John Wiley & Sons Ltd.
- Resource Type
- journal article
- Date
- 2022
- Description
- Introduction: Head and neck cancer (HNC) patients are at risk of weight change, due to inadequate nutrition intake or dehydration, when receiving radiotherapy (RT). This study aimed to develop methodology to measure water content changes on magnetic resonance imaging (MRI) scans of the head and neck region over the course of RT. Methods: Retrospective datasets of 54 patients were analysed. Eligible patients had been treated for HNC with cisplatin chemoradiation (CRT) or RT alone and underwent a minimum of 2 MRI scans from weeks 0, 3 and 6 of their treatment. Anatomical regions consisting of ≥90% water, on T2-weighted DIXON MRI sequences, were contoured. Water volume changes of all patients were evaluated, within an anatomically standardised external volume, by comparing the absolute water fraction volume (cc) (VEx90WF) and relative water fraction volume (%) (RelVEx90WF) at weeks 0 and 6 of RT. Results: There was a statistically significant difference between the RelVEx90WF at weeks 0 and 6 (P = 0.005). However, no statistically significant difference was identified between weeks 0 and 6 VEx90WF (P = 0.064). There were no statistically significant differences identified between patients who received CRT versus RT alone. Conclusion: This study developed a novel method for measuring changes in water fraction volumes over time, using T2-weighted DIXON MRIs. The methodology created in this study requires further validation through phantom imaging, with known fat and water values.
- Subject
- head and neck; clinical site; magnetic resonance imaging; radiotherapy; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1491137
- Identifier
- uon:53033
- Identifier
- ISSN:2051-3895
- Rights
- © 2022 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2245
- Visitors: 2245
- Downloads: 9
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 582 KB | Adobe Acrobat PDF | View Details Download |