- Title
- Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency
- Creator
- Simone, Michela I.; Wood, Adam; Campkin, David; Kiefel, Milton J.; Houston, Todd A.
- Relation
- European Journal of Medicinal Chemistry Vol. 235, no. 114282
- Publisher Link
- http://dx.doi.org/10.1016/j.ejmech.2022.114282
- Publisher
- Elsevier Masson
- Resource Type
- journal article
- Date
- 2022
- Description
- This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.
- Subject
- benzimidazole; chalcone; cinnamic acid; coumarin; flavonoid
- Identifier
- http://hdl.handle.net/1959.13/1489759
- Identifier
- uon:52765
- Language
- eng
- Reviewed
- Hits: 825
- Visitors: 823
- Downloads: 0
| Thumbnail | File | Description | Size | Format |
|---|