Design of respirable sprayed microparticles of encapsulated bacteriophages

Title: Design of respirable sprayed microparticles of encapsulated bacteriophages
Creator: Baldelli, Alberto; Liang, Mingtao
Relation: Frontiers in Drug Delivery Vol. 3, no. 1209534
Publisher Link: http://dx.doi.org/10.3389/fddev.2023.1209534
Publisher: Frontiers Research Foundation
Resource Type: journal article
Date: 2023
Description: Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections is expected to surge. When dealing with the respiratory system, inefficient antibiotics heighten the chance of death from bacterial infection. However, the alternatives to antibiotics are limited. Bacteriophages are a valid option since they can target a specific type of bacterium. Bacteriophages are highly specific and can avoid any side effects when delivered. However, their poor stability makes their use inefficient. Encapsulation is commonly used to protect any bioactive compound for different types of delivery. In the case of respiratory delivery, particle engineering is used to generate stable dry powders to target the nasal or lung areas. This review article provides a guideline for engineering a process of nasal dry powders of encapsulated bacteriophages.
Subject: particle engineering; respiratory delivery; spraying techniques; phage therapy; bacteriophage
Identifier: http://hdl.handle.net/1959.13/1488972
Identifier: uon:52584
Identifier: ISSN:2674-0850
Language: eng
Reviewed

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