- Title
- How little is enough? The feasibility of conducting a dose-escalation study for exercise training in people with stroke
- Creator
- Galloway, Margaret; Marsden, Dianne L.; Callister, Robin; Erickson, Kirk I.; Nilsson, Michael; English, Coralie
- Relation
- Journal of Stroke and Cerebrovascular Diseases Vol. 32, Issue 8, no. 107190
- Publisher Link
- http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2023.107190
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2023
- Description
- Question: Is it feasible and safe to conduct an exercise dose-finding study in people with stroke? Is it possible to determine a minimal dose of exercise required to see clinically meaningful improvements in cardiorespiratory fitness? Methods: Dose-escalation study. Twenty people with stroke (n=5 per cohort) who were able to walk independently participated in home-based, telehealth-supervised aerobic exercise sessions 3 d/week at moderate-vigorous intensity for 8 weeks. Dose parameters of frequency (3 d/week), intensity (55-85% of heart rate peak) and program length (8 weeks) were kept constant. The duration of exercise sessions was increased by 5 min per session from Dose 1 (10 min/session) to Dose 4 (25 min/session). Doses were escalated if safe and tolerable (< 33% of a cohort reaching a dose-limiting threshold). Doses were efficacious if ≥ 67% of a cohort increased peak oxygen consumption ≥ 2mL/kg/min. Results: Target exercise doses were well adhered to, and the intervention was safe (480 exercise sessions delivered; one fall resulting in minor laceration) and tolerable (no participants met the dose-limiting threshold). None of the exercise doses met our criterion for efficacy. Conclusions: It is possible to conduct a dose-escalation trial for people with stroke. The small cohort sizes may have limited the ability to determine an efficacious minimum dose of exercise. Providing supervised exercise session at these prescribed doses via telehealth was safe. Registration: The study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000460303).
- Subject
- stroke; exercise dose; cardiorespiratory fitness; exercise; telemedicine; rehabilitation
- Identifier
- http://hdl.handle.net/1959.13/1487882
- Identifier
- uon:52271
- Identifier
- ISSN:1052-3057
- Rights
- X
- Language
- eng
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