- Title
- E-Cigarette Vapour Alters High-Fat Diet-Induced Systemic Inflammatory Responses but Has No Effect on High-Fat Diet-Induced Changes in Gut Microbiota
- Creator
- Chen, Hui; Burke, Catherine; Donovan, Chantal; Faiz, Alen; Saad, Sonia; Oliver, Brian G.
- Relation
- Nutrients Vol. 15, Issue 7, no. 1783
- Publisher Link
- http://dx.doi.org/10.3390/nu15071783
- Publisher
- MDPI
- Resource Type
- journal article
- Date
- 2023
- Description
- BACKGROUND: The gut microbiome, which can be altered by different diets or smoking, has been implicated in the pathogenesis of lung conditions. E-cigarette vaping is now recognised to have detrimental health effects, with several of these being similar to cigarette smoking. However, whether e-cigarettes can alter high-fat diet (HFD)-induced systemic effects and gut microbiota is unknown. In this study, we investigated the effects of HFD in the absence/presence of e-cigarette exposure on systemic inflammation, lipid metabolic markers, and the gut microbiome. METHODS: Mice were fed a HFD (or chow) in the absence/presence of e-vapour exposure (±nicotine) and serum inflammation, lipid levels, and microbial diversity were assessed. RESULTS: HFD increased the circulating levels of both triglycerides and non-esterified fatty acids, which were significantly reduced by e-vapour exposure in HFD-fed mice. Serum TNF-α was increased by HFD consumption or e-vapour. HFD had a significant effect on microbial diversity, but there were no additional effects of e-vapour exposure. CONCLUSIONS: This study highlights both similarities and differences in how the body responds to e-cigarette vapours, and it is therefore likely that the long-term sequelae of e-cigarette vapour exposure/vaping might not involve the significant alteration of the gut microbiome.
- Subject
- e-cigarettes; e-vapour; high-fat diet; microbiome; gut microbiota; lipids
- Identifier
- http://hdl.handle.net/1959.13/1484693
- Identifier
- uon:51401
- Identifier
- ISSN:2072-6643
- Language
- eng
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