- Title
- Effectiveness of Interventions Targeting Treatable Traits for the Management of Obstructive Airway Diseases: A Systematic Review and Meta-Analysis
- Creator
- Sarwar, Muhammad Rehan; McDonald, Vanessa Marie; Abramson, Michael John; McLoughlin, Rebecca Frances; Geethadevi, Gopisankar Mohanannair; George, Johnson
- Relation
- Journal of Allergy and Clinical Immunology: In Practice Vol. 10, Issue 9, p. 2333-2345.e21
- Publisher Link
- http://dx.doi.org/10.1016/j.jaip.2022.05.012
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2022
- Description
- Background: The management of obstructive airway diseases (OADs) is complex. The treatable traits (TTs) approach may be an effective strategy for managing OADs. Objective: To determine the effectiveness of interventions targeting TTs for managing OADs. Methods: Ovid Embase, Medline, CENTRAL, and CINAHL Plus were searched from inception to March 9, 2022. Studies of interventions targeting at least 1 TT from pulmonary, extrapulmonary, and behavioral/lifestyle domains were included. Two reviewers independently extracted relevant data and performed risk-of-bias assessments. Meta-analyses were performed using random-effects models. Subgroup and sensitivity analyses were carried out to explore heterogeneity and to determine the effects of outlying studies. Results: Eleven studies that used the TTs approach for OAD management were identified. Traits targeted within each study ranged from 13 to 36. Seven controlled trials were included in meta-analyses. TT interventions were effective at improving health-related quality of life (mean difference [MD] = −6.96, 95% CI: −9.92 to −4.01), hospitalizations (odds ratio [OR] = 0.52, 95% CI: 0.39 to 0.69), all-cause-1-year mortality (OR = 0.65, 95% CI: 0.45 to 0.95), dyspnea score (MD = −0.29, 95% CI: −0.46 to −0.12), anxiety (MD = −1.61, 95% CI: −2.92 to −0.30), and depression (MD = −2.00, 95% CI: −3.53 to −0.47). Conclusion: Characterizing TTs and targeted interventions can improve outcomes in OADs, which offer a promising model of care for OADs.
- Subject
- treatable traits; obstructive airway diseases; asthma; chronic obstructive pulmonary disease; asthma-COPD overlap; multidimensional assessment; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1482085
- Identifier
- uon:50855
- Identifier
- ISSN:2213-2198
- Language
- eng
- Reviewed
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