An update in club cell biology and its potential relevance to chronic obstructive pulmonary disease

Title: An update in club cell biology and its potential relevance to chronic obstructive pulmonary disease
Creator: Blackburn, Jessica B.; Li, Ngan Fung; Bartlett, Nathan W.; Richmond, Bradley W.
Relation: American Journal of Physiology - Lung Cellular and Molecular Physiology Vol. 324, Issue 5, p. L652-L665
Publisher Link: http://dx.doi.org/10.1152/ajplung.00192.2022
Publisher: American Physiological Society
Resource Type: journal article
Date: 2023
Description: Club cells are found in human small airways where they play an important role in immune defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from single-cell RNA sequencing (scRNA-seq) studies has generated new insights into club cell heterogeneity and function. In this review, we integrate findings from scRNA-seq experiments with earlier in vitro, in vivo, and microscopy studies and highlight the many ways club cells contribute to airway homeostasis. We then discuss evidence for loss of club cells or club cell products in the airways of patients with chronic obstructive pulmonary disease (COPD) and discuss potential mechanisms through which this might occur.
Subject: club cells; COPD; scRNA-seq; secretory cells; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1481150
Identifier: uon:50653
Identifier: ISSN:1040-0605
Language: eng
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