- Title
- Paracrine Factors Released by Stem Cells of Mesenchymal Origin and their Effects in Cardiovascular Disease: A Systematic Review of Pre-clinical Studies
- Creator
- Mabotuwana, Nishani S.; Rech, Lavinia; Lim, Joyce; Hardy, Sean A.; Murtha, Lucy A.; Rainer, Peter P.; Boyle, Andrew J.
- Relation
- Stem Cell Reviews and Reports Vol. 18, Issue 8, p. 2606-2628
- Publisher Link
- http://dx.doi.org/10.1007/s12015-022-10429-6
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2022
- Description
- Mesenchymal stem cell (MSC) therapy has gained significant traction in the context of cardiovascular repair, and have been proposed to exert their regenerative effects via the secretion of paracrine factors. In this systematic review, we examined the literature and consolidated available evidence for the “paracrine hypothesis”. Two Ovid SP databases were searched using a strategy encompassing paracrine mediated MSC therapy in the context of ischemic heart disease. This yielded 86 articles which met the selection criteria for inclusion in this study. We found that the MSCs utilized in these articles were primarily derived from bone marrow, cardiac tissue, and adipose tissue. We identified 234 individual protective factors across these studies, including VEGF, HGF, and FGF2; which are proposed to exert their effects in a paracrine manner. The data collated in this systematic review identifies secreted paracrine factors that could decrease apoptosis, and increase angiogenesis, cell proliferation, and cell viability. These included studies have also demonstrated that the administration of MSCs and indirectly, their secreted factors can reduce infarct size, and improve left ventricular ejection fraction, contractility, compliance, and vessel density. Furthering our understanding of the way these factors mediate repair could lead to the identification of therapeutic targets for cardiac regeneration.
- Subject
- mesenchymal stem cell; paracrine; secreted; myocardial ischemia; cardiac repair; cardiac regeneration; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1480640
- Identifier
- uon:50545
- Identifier
- ISSN:2629-3269
- Rights
- © Crown 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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