- Title
- A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine
- Creator
- Dzator, Jemima S. A.; Howe, Peter R. C.; Coupland, Kirsten G.; Wong, Rachel H. X.
- Relation
- Nutrients Vol. 14, Issue 9, no. 1763
- Publisher Link
- http://dx.doi.org/10.3390/nu14091763
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2022
- Description
- Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular func-tion. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. A randomised, double-blind, placebo-controlled, crossover, intervention trial was con-ducted in 62 hormonal migraineurs (mean age: 37.5 ± 0.8 years). Participants consumed 75 mg of resveratrol or matching placebo capsules twice daily for three months before crossing over to the other treatment arm. Participants completed a daily diary and the Headache Impact Test-6™, Migraine Disability Assessment and Migraine-Specific Quality of Life questionnaires at months 0, 3 and 6. The HMBI was the primary outcome and was calculated using data extracted from the par-ticipant’s diary. No differences in the HMBI (p = 0.895), the Headache Impact Test-6™, the Migraine Disability Assessment and Migraine-Specific Quality of Life were found between the resveratrol and placebo treatments. Resveratrol supplementation for three months did not affect the HMBI, the migraine-related disability or quality of life measures in our cohort of hormonal migraineurs.
- Subject
- resveratrol; phytoestrogen; nutrient intervention; cerebrovascular function; hormonal migraine; prophylaxis
- Identifier
- http://hdl.handle.net/1959.13/1480016
- Identifier
- uon:50429
- Identifier
- ISSN:2072-6643
- Rights
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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