Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs

Title: Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs
Creator: Yang, Ming; Mattes, Joerg
Relation: Pharmacology & Therapeutics Vol. 117, Issue 1, p. 94-104
Publisher Link: http://dx.doi.org/10.1016/j.pharmthera.2007.08.004
Publisher: Elsevier
Resource Type: journal article
Date: 2008
Description: The discovery of small RNA molecules as regulators of posttranscriptional gene silencing has paved the way to specifically target any given protein via the RNA interference (RNAi) pathway. An endogenous class of these molecules, the microRNA (miRNA), is proposed to control expression of up to one third of all genes and may be utilized as diagnostic and prognostic marker for diseases. In addition the recent employment of antagomirs that specifically inhibit function of a given miRNA represents a powerful tool to determine the role of these molecules in disease pathogenesis. Here, we describe our current understanding of the structure, biogenesis and function of small RNA, as well as their potential and limitation as novel therapeutic approaches.
Subject: short interference RNA; short hairpin RNA; microRNA; antagomirs; gene regulation; therapy
Identifier: uon:5035
Identifier: http://hdl.handle.net/1959.13/42896
Identifier: ISSN:0163-7258
Reviewed

		Thumbnail	File	Description	Size	Format