- Title
- The double life of RIPK1
- Creator
- Jin, Lei; Chen, Jiezhong; Liu, Xiao Ying; Jiang, Chen Chen; Zhang, Xu Dong
- Relation
- Molecular and Cellular Oncology Vol. 3, Issue 1, no. e1035690
- Publisher Link
- http://dx.doi.org/10.1080/23723556.2015.1035690
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2016
- Description
- We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.
- Subject
- cell death; cell proliferation; death receptor; melanoma; NF-kB; RIPK1; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1479625
- Identifier
- uon:50344
- Identifier
- ISSN:2372-3556
- Language
- eng
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