- Title
- Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies
- Creator
- McPherson, Zachary E.; Sørensen, Henrik T.; Talley, Nicholas J.; McEvoy, Mark A.; Horváth-Puhó, Erzsébet; Agar, Ashish; Coroneo, Minas T.; White, Andrew; Francis, Ian C.; Pasquale, Louis R.; Kang, Jae H.; Pettersson, Sven
- Relation
- United European Gastroenterology Journal Vol. 9, Issue 9, p. 1057-1065
- Publisher Link
- http://dx.doi.org/10.1002/ueg2.12136
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2021
- Description
- Objective: Irritable bowel syndrome (IBS) is a chronic disorder associated with an abnormal gastrointestinal microbiome. Microbiome–host interactions are known to influence organ function including in the central nervous system; thus, we sought to identify whether IBS may be a risk factor for the development of glaucoma. Design: Two prospective cohort studies. Subjects: The 1958 United Kingdom Birth Cohort (UKBC; 9091 individuals) and the Danish National Registry of Patients (DNRP; 62,541 individuals with IBS and 625,410 matched general population cohort members). Methods: In the UKBC, participants were surveyed throughout life (including at ages 42 and 50). The DNRP contains records of hospital-based contacts and prescription data from the national prescription database. Main Outcome Measure: The main outcome measure was incidence of glaucoma. In the UKBC, incident glaucoma at age 50 (n = 48) was determined through comparison of survey responses at ages 42 and 50 years. In the DNRP, glaucoma was assessed by hospital diagnosis (n = 1510), glaucoma surgery (n = 582) and initiation of glaucoma medications (n = 1674). Results: In the UKBC, the odds ratio (OR) of developing glaucoma between ages 42 and 50 in persons with a chronic IBS diagnosis was increased [OR: 5.84, 95% confidence interval (CI): 2.26–15.13]. People with an IBS diagnosis in the DNRP had a hazard ratio (HR) of 1.35 for developing physician-diagnosed glaucoma (95% CI: 1.16–1.56), an HR of 1.35 for undergoing glaucoma surgery (95% CI: 1.06–1.70) and an HR of 1.19 for initiating glaucoma medication (95% CI: 1.03–1.38). Conclusions: In two large European cohort studies, IBS is a risk factor for glaucoma.
- Subject
- cohort studies; glaucoma; irritable bowel syndrome; risk factor
- Identifier
- http://hdl.handle.net/1959.13/1476897
- Identifier
- uon:49881
- Identifier
- ISSN:2050-6406
- Language
- eng
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