- Title
- MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
- Creator
- Clarke, Laura; Arnett, Simon; Bundell, Christine S.; Abernethy, David A.; Bhuta, Sandeep; Blum, Stefan; Boggild, Mike; Boundy, Karyn; Brew, Bruce J.; Brownlee, Wallace; Butzkueven, Helmut; Carroll, William M.; Bukhari, Wajih; Chen, Cella; Coulthard, A; Dale, RC; Das, C; Fabis-Pedrini, MJ; Gillis, D; Hawke, S; Heard, R; Henderson, APD; Heshmat, S; Khalilidehkordi, Elham; Hodgkinson, S; Kilpatrick, TJ; King, J; Kneebone, C; Kornberg, AJ; Lechner-Scott, Jeannette; Lin, M-W; Lynch, C; Macdonell, RAL; Mason, DF; Sanchez, Sofia Jimenez; McCombe, PA; Pereira, J; Pollard, JD; Ramanathan, S; Reddel, SW; Shaw, CP; Spies, JM; Stankovich, J; Sutton, I; Vucic, S; O'Gorman, Cullen; Walsh, M; Wong, RC; Yiu, EM; Barnett, MH; Kermode, AGK; Marriott, MP; Parratt, JDE; Slee, M; Taylor, B; Willoughby, E; Sun, Jing; Brilot, F; Vincent, A; Waters, P; Broadley, SA; Prain, Kerri M.; Woodhall, Mark; Silvestrini, Roger
- Relation
- Frontiers in Neurology Vol. 12, Issue 9 September 2021, no. 722237
- Publisher Link
- http://dx.doi.org/10.3389/fneur.2021.722237
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2021
- Description
- Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), “bright spotty” (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS.
- Subject
- neuromyelitis optica; multiple sclerosis; magnetic resonance imaging; diagnosis; neuromyelitis optica spectrum disorder (NMOSD)
- Identifier
- http://hdl.handle.net/1959.13/1476336
- Identifier
- uon:49799
- Identifier
- ISSN:1664-2295
- Rights
- © 2021 Clarke, Arnett, Bukhari, Khalilidehkordi, Jimenez Sanchez, O'Gorman, Sun, Prain, Woodhall, Silvestrini, Bundell, Abernethy, Bhuta, Blum, Boggild, Boundy, Brew, Brownlee, Butzkueven, Carroll, Chen, Coulthard, Dale, Das, Fabis-Pedrini, Gillis, Hawke, Heard, Henderson, Heshmat, Hodgkinson, Kilpatrick, King, Kneebone, Kornberg, Lechner-Scott, Lin, Lynch, Macdonell, Mason, McCombe, Pereira, Pollard, Ramanathan, Reddel, Shaw, Spies, Stankovich, Sutton, Vucic, Walsh, Wong, Yiu, Barnett, Kermode, Marriott, Parratt, Slee, Taylor, Willoughby, Brilot, Vincent, Waters and Broadley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 13787
- Visitors: 13886
- Downloads: 111
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 5 MB | Adobe Acrobat PDF | View Details Download |