- Title
- Efficacy of resveratrol encapsulated microsponges delivered by pectin based matrix tablets in rats with acetic acid-induced ulcerative colitis
- Creator
- Gandhi, Himanshu; Rathore, Charul; Dua, Kamal; Vihal, Samar; Tambuwala, Murtaza M.; Negi, Poonam
- Relation
- Drug Development and Industrial Pharmacy Vol. 46, Issue 3, p. 365-375
- Publisher Link
- http://dx.doi.org/10.1080/03639045.2020.1724127
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2020
- Description
- Objectives: The objective of the present work to encapsulate the resveratrol (RES) inside the chitosan-based microsponges, employing the systematic optimization by 33 Box–Behnken design for the colonic targeting. Significance: Enhanced therapeutic efficacy of RES-loaded microsponges and matrix tablets, vis-a-vis pureRES for ulcerative colitis. Methods: RES-loaded microsponges were prepared employing the systematic optimization by 33 Box–Behnken design for the colonic targeting. The best-optimizedRES-loaded microsponge was compressed in the form of a tablet, employing pectin as a matrix-forming material. The encapsulation of RES inside microsponge was confirmed by XRD, DSC and FT-IR. Further, both RES-loaded microsponges and matrix tablets were evaluated for in vitro release kinetics and further evaluated for in vivo ulcerative colitis animal model. Results: Optimization experiments was obtained as the high value of r2 (particle size = 0.9999; %EE = 0.9652; %CDR = 0.9469) inferred excellent goodness of fit. SEM revealed nearly spherical and porous nature of RES-loaded microsponges. The in vitro release kinetic showed zero-order release for RES-loaded microsponges and Korsmeyer–Peppas model for matrix tablets. The pharmacodynamic studies, in ulcerative colitis rat model, indicated better therapeutic efficacy of drug-loaded microsponges and matrix tablets, vis-a-vis pure RES. Thus, the present study advocates the potential of RES based microsponges delivered by pectin based matrix tablet, in the treatment of various colonic disorders. Conclusion: The present study proved that RES-loaded microsponges and matrix tablets based on chitosan and pectin can be the ideal delivery system for colonic delivery of RES.
- Subject
- chitosan; Box-Behnken design; quasi emulsion solvent diffusion method; pectin; ulcerative colitis; release kinetics
- Identifier
- http://hdl.handle.net/1959.13/1476121
- Identifier
- uon:49740
- Identifier
- ISSN:0363-9045
- Language
- eng
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