- Title
- 6-nitro-7-tosylquinazolin-4(3h)-one
- Creator
- Nguyen, Thi Ngoc; Tran, Thi Phuong Thuy; Vu, Thi Hoang Mai; Nguyen, Hoa Binh; Dao, Nguyet Suong Huyen; Nguyen, Van Giang; Nguyen, Dinh Luyen; Trinh, Nguyen Trieu; Nguyen, Van Hai
- Relation
- MolBank Vol. 2020, Issue 4, no. M1168, p. 1-7
- Publisher Link
- http://dx.doi.org/10.3390/M1168
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2020
- Description
- Sulfones are important building blocks in the construction of biologically active molecules or functional materials. The sulfonyl functional group in sulfones is so versatile that it can act as either a nucleophile, an electrophile, or a radical in different organic reactions. Recently, quinazoline sulfones have been used to build asymmetrical ether derivatives as inhibitors of signaling pathways governed by tyrosine kinases and the epidermal growth factor-receptor. In this paper, we report a facile synthesis of a novel quinazoline sulfone, 6-nitro-7-tosylquinazolin-4(3H)-one (III), using the modified protocol from 7-chloro-6-nitroquinazolin-4(3H)-one (I) and sodium p-toluenesulfinate (II). The structure of the title compound III was determined using mass-spectrometry, FT-IR,1H-NMR,13C-NMR, DEPT, HSQC (Heteronuclear single quantum coherence), HMBC (Heteronuclear Multiple Bond Correlation Spectroscopy) spectroscopies, and PXRD analysis.
- Subject
- 7-chloro-6-nitroquinazolin-4(3H)-one; 6-nitro-7-tosylquinazolin-4(3H)-one; sulfinate; sulfone
- Identifier
- http://hdl.handle.net/1959.13/1476006
- Identifier
- uon:49720
- Identifier
- ISSN:1422-8599
- Language
- eng
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