- Title
- The impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization
- Creator
- Aitken, R. John; Bromfield, Elizabeth G.; Gibb, Zamira
- Relation
- Reproduction Vol. 164, Issue 6, p. F79-F94
- Publisher Link
- http://dx.doi.org/10.1530/rep-22-0126
- Publisher
- BioScientifica
- Resource Type
- journal article
- Date
- 2022
- Description
- This article lays out the fundamental principles of oxidative stress. It describes the nature of reactive oxygen species (ROS), the way in which these potentially toxic metabolites interact with cells and how they impact both cellular function and genetic integrity. The mechanisms by which ROS generation is enhanced to the point that the cells' antioxidant defence mechanisms are overwhelmed are also reviewed taking examples from both the male and female reproductive system, with a focus on gametogenesis and fertilization. The important role of external factors in exacerbating oxidative stress and impairing reproductive competence is also examined in terms of their ability to disrupt the physiological redox regulation of reproductive processes. Developing diagnostic and therapeutic strategies to cope with oxidative stress within the reproductive system will depend on the development of a deeper understanding of the nature, source, magnitude, and location of such stress in order to fashion personalized treatments that meet a given patient's clinical needs.
- Subject
- reproductive process; oxidative stress; reactive oxygen species (ROS); patient's clinical needs
- Identifier
- http://hdl.handle.net/1959.13/1475831
- Identifier
- uon:49666
- Identifier
- ISSN:1470-1626
- Language
- eng
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