Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Title: Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort
Creator: Davis, Joshua S.; Metcalf, Sarah; Paterson, David L.; Robinson, James O.; Clarke, Benjamin; Manning, Laurens
Relation: Internal Medicine Journal Vol. 52, Issue 2, p. 322-325
Publisher Link: http://dx.doi.org/10.1111/imj.15677
Publisher: John Wiley & Sons
Resource Type: journal article
Date: 2022
Description: Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.
Subject: prosthetic joint infection; empirical antibiotics; septic arthritis; infections
Identifier: http://hdl.handle.net/1959.13/1472843
Identifier: uon:48933
Identifier: ISSN:1444-0903
Language: eng
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