- Title
- Genetic overlap between endometriosis and endometrial cancer: Evidence from cross-disease genetic correlation and GWAS meta-analyses
- Creator
- Painter, Jodie N.; O'Mara, Tracy A.; Henders, Anjali K.; Attia, John; McEvoy, Mark; Holliday, Elizabeth G.; Scott, Rodney J.; Webb, Penelope M.; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hein, Alexander; Morris, Andrew P.; Rübner, Matthias; Hall, P; Czene, K; Dörk, T; Dürst, M; Hillemanns, P; Runnebaum, I; Lambrechts, D; Amant, F; Annibali, D; Cheng, Timothy H. T.; Depreeuw, J; Vanderstichele, A; Goode, EL; Cunningham, JM; Dowdy, SC; Winham, SJ; Trovik, J; Hoivik, E; Werner, HMJ; Krakstad, C; Gorman, Maggie; Ashton, Katie; Otton, Geoffrey; Proietto, Tony; Tham, E; Mints, M; Ahmed, S; Healey, CS; Shah, M; Pharoah, PDP; Dunning, AM; Martin, Lynn; Dennis, J; Bolla, MK; Michailidou, K; Wang, Q; Tyrer, JP; Hopper, JL; Peto, J; Swerdlow, AJ; Burwinkel, B; Brenner, H; Hodson, Shirley; Meindl, A; Brauch, H; Lindblom, A; Chang-Claude, J; Couch, FJ; Giles, GG; Kristensen, VN; Cox, A; Zondervan, KT; Nyholt, DR; Jones, Angela; Macgregor, S; Montgomery, GW; Martin, Nnicholas G.; Gordon, Scott
- Relation
- Cancer Medicine Vol. 7, Issue 5, p. 1978-1987
- Publisher Link
- http://dx.doi.org/10.1002/cam4.1445
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2018
- Description
- Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regression revealed moderate but significant genetic correlation (rg = 0.23, P = 9.3 × 10−3), and SNP effect concordance analysis provided evidence for significant SNP pleiotropy (P = 6.0 × 10−3) and concordance in effect direction (P = 2.0 × 10−3) between the two diseases. Cross-disease GWAS meta-analysis highlighted 13 distinct loci associated at P ≤ 10−5 with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10−8, OR = 1.11, 95% CI = 1.07–1.15). PTPRD acts in the STAT3 pathway, which has been implicated in both endometriosis and endometrial cancer. This study demonstrates the value of cross-disease genetic analysis to support epidemiological observations and to identify biological pathways of relevance to multiple diseases.
- Subject
- cross‐disease analysis; endometrial cancer; endometriosis; genome‐wide association study; genetic correlation; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1472364
- Identifier
- uon:48810
- Identifier
- ISSN:2045-7634
- Rights
- © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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